Evidence map›Paper›PMID 40631071›Full record

ArticlebioRxiv : the preprint server for biology2025

REGULATORY T CELLS PROTECT AGAINST ABERRANT REMODELING IN A MOUSE MODEL OF PULMONARY FIBROSIS.

Aditi Murthy, Luis R Rodríguez, Willy Roque Barboza, Yaniv Tomer, Sarah Bui, Paige Carson, Thalia Dimopoulos, Swati Iyer, Katrina Chavez, Charlotte H Cooper and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Aditi MurthyPulmonary, Allergy, and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.ORCID 0009-0004-6983-4836
Luis R RodríguezPulmonary, Allergy, and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.ORCID 0000-0001-7176-0697
Willy Roque BarbozaPulmonary, Allergy, and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Yaniv TomerPulmonary, Allergy, and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Sarah BuiPulmonary, Allergy, and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Paige CarsonPulmonary, Allergy, and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Thalia DimopoulosPulmonary, Allergy, and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Swati IyerPulmonary, Allergy, and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Katrina ChavezPulmonary, Allergy, and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Charlotte H CooperPulmonary, Allergy, and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Jeremy B KatzenPulmonary, Allergy, and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Michael F BeersPulmonary, Allergy, and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.ORCID 0000-0002-2149-3209

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3M
TRAINING IN PULMONARY IMMUNOLOGYT32HL007586 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 1985 to 2025
$8.8M
Alveolar Epithelial Cell Dysfunction in Pulmonary Fibrosis: Leveraging SFTPC Mutations for Discovery of Molecular and Cellular TargetsR01HL145408 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MICHAEL FRANCIS BEERS · 2019 to 2026
$4.6M
Surfactant Protein C Mouse Models: A Fit For Purpose Preclinical Platform For Advancing Discovery In And Treatment Of Idiopathic Pulmonary FibrosisU01HL152970 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BEERS, MICHAEL FRANCIS · 2021 to 2024
$3.0M
Biosynthesis and Trafficking of Surfactant Protein C In Health and DiseaseR01HL119436 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BEERS, MICHAEL FRANCIS · 2013 to 2017
$2.0M
Understanding how alveolar epithelial cell stress drives aberrant repair in interstitial lung diseaseK08HL150226 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KATZEN, JEREMY BINDER · 2020 to 2024
$840k
Aging and Metabolic Dysfunction Drive Disrupted Alveolar Epithelial Progenitor Function in Pulmonary FibrosisK99HL171946 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RODRIGUEZ, LUIS R · 2024 to 2024
$163k
The role of Alveolar Epithelial Cell Metabolic Reprogramming in Idiopathic Pulmonary FibrosisF32HL160011 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RODRIGUEZ, LUIS R · 2021 to 2021
$71k
BLRD VA I01 BX001176NHLBI NIH HHS F32 HL160011NHLBI NIH HHS K08 HL150226NHLBI NIH HHS K99 HL171946NHLBI NIH HHS R01 HL119436NHLBI NIH HHS R01 HL145408NHLBI NIH HHS T32 HL007586NHLBI NIH HHS U01 HL152970NIEHS NIH HHS P30 ES013508
6 · The paper itself

Abstract

Regulatory T (Treg) cells are well recognized for their role in immune regulation; however, their role in tissue regeneration is not fully understood. This study demonstrates such a role of Tregs in a published preclinical murine model of spontaneous pulmonary fibrosis (PF) expressing a human PF related mutation in the Surfactant Protein-C (SP-C) gene (

Indexed as

Alveolar Type 2 Epithelial CellAmphiregulinLung FibroblastLung RemodelingTreg

Identifiers

PMID40631071
PMCPMC12236608

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.