Evidence map›Paper›PMID 40631045›Full record

ArticleAdvanced therapeutics2025

CLINICALLY RELEVANT METALLIC NANOPARTICLES IN TUBERCULOSIS DIAGNOSIS AND THERAPY.

Christianah Aarinola Akinnawo, Admire Dube

Abstract read
In one paragraph

Article in Advanced therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christianah Aarinola AkinnawoSchool of Pharmacy, University of the Western Cape, Bellville 7535, South Africa.
Admire DubeSchool of Pharmacy, University of the Western Cape, Bellville 7535, South Africa.

Funding

Nanoparticle-based host-directed therapies for eradication of Mycobacterium tuberculosisR01AI152109 · NIAID · STELLENBOSCH UNIVERSITY · PI DUBE, ADMIRE, REINEKE, JOSHUA JAMES · 2020 to 2024
$1.6M
NIAID NIH HHS R01 AI152109
6 · The paper itself

Abstract

Globally we are faced with a significant burden of tuberculosis (TB), which is difficult to eradicate due to patients' non-adherance, and drug-resistant strains that are spreading at an alarming rate. Novel approaches are required to improve diagnosis and treatment. Metallic nanoparticles (MNPs) have demonstrated potential as sensor probes and in combination therapy, which combines MNPs with antimycobacterial drugs to develop new treatment and theranostic approaches. To strengthen the theoretical foundation towards the clinical application of TB nanomedicine, this review focuses on the properties and effectiveness of therapeutically relevant MNPs. We also elaborate on their antimycobacterial mechanisms. This review aims to analyze the body of literature on the topic, pinpoint important empirical findings, and identify knowledge gaps that could provide a basis for future research endeavors and translation of the technologies. Current data suggest that MNPs are potential systems for efficient diagnosis and treatment although additional pre-clinical and clinical research is needed to bring these technologies to the clinic.

Indexed as

antimycobacterial treatmentsmetal nanocompositesmetal nanoparticlesmetal oxide nanoparticlesTB diagnosistheranostic applications in TBTuberculosis

Identifiers

PMID40631045
PMCPMC12233216

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.