ArticleJTCVS open2025
Acute loss of mitral annular dynamics predicts development of functional mitral regurgitation after myocardial infarction in a swine model.
Article in JTCVS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Functional mitral regurgitation is identified in approximately 40% of patients after myocardial infarction, adversely affecting their prognosis. Predicting functional mitral regurgitation development after the onset of myocardial infarction remains challenging, yet early intervention could potentially enhance patient outcomes. In this study, we developed porcine models with consistent lateral wall infarction to investigate the morphological and functional differences between animals with functional mitral regurgitation and those without. Methods: Twenty-two Yorkshire pigs underwent myocardial infarction induction through occlusion of the left circumflex coronary artery. Epicardial echocardiography and pressure-volume loop analysis were performed before and after myocardial infarction induction. Three months after myocardial infarction, mitral regurgitation quantification was conducted with epicardial echocardiography via mini left thoracotomy, and the animals were classified into 2 groups based on mitral regurgitation severity: no/mild mitral regurgitation (lower mitral regurgitation, n = 11) and moderate/severe mitral regurgitation (greater mitral regurgitation, n = 11). The left ventricle and mitral valve geometry and function immediately after myocardial infarction were compared between the 2 groups. Results: The infarction area was comparable between the groups, with no significant differences observed in invasive hemodynamic parameters after myocardial infarction. However, the change in the mitral annular anteroposterior diameter (diastolic anteroposterior minus systolic anteroposterior) immediately after myocardial infarction was significantly lower in the greater mitral regurgitation group (2.02 ± 1.19 vs 4.34 ± 0.93, Conclusions: Reduced anteroposterior diameter shortening from diastole to systole, indicative of impaired annular dynamics, immediately after myocardial infarction can serve as a new predictor for the subsequent development of mitral regurgitation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.