Evidence map›Paper›PMID 40631006›Full record

ArticleJTCVS open2025

Sex differences persist across surgical treatments in early-stage non-small cell lung cancer.

Jessica Copeland, Tayyiaba Farooq, Sophia Phillips, Taelyr Blehm, Grace Drew, Endel Orav

Abstract read
In one paragraph

Article in JTCVS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jessica CopelandDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass.
Tayyiaba FarooqRowan-Virtua School of Osteopathic Medicine, Stratford, NJ.
Sophia PhillipsThe National Center for Health Research, Washington, DC.
Taelyr BlehmThe National Center for Health Research, Washington, DC.
Grace DrewThe National Center for Health Research, Washington, DC.
Endel OravDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Mass.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Sex-based overall survival in patients with early-stage non-small cell lung cancer who undergo surgery is not well characterized. Existing data are limited by small sample sizes and underrepresentation of female patients or do not address overall survival according to surgical approach. The objective of this study was to compare overall survival among female and male patients with early-stage non-small cell lung cancer who underwent surgery. Methods: Data were extracted from the National Cancer Database for all patients diagnosed with clinical stage I-IIB non-small cell lung cancer who underwent surgical resection from 2009 to 2018, had R Results: Of the 79,209 patients included in the study sample, 43,218 (54.6%) were female. A propensity score-matched analysis of 23,988 female and 23,988 male patients with early-stage non-small cell lung cancer who underwent surgery showed that the female group had significantly improved 5-year overall survival at 71.2% (95% CI, 70.5-71.8) compared with the male group at 61.7% (95% CI, 61.0-62.4) (log-rank, Conclusions: Female patients with early-stage non-small cell lung cancer who underwent surgery had significantly better overall survival at 5 years when compared with their male counterparts.

Indexed as

non–small cell lung canceroverall survivalsex differencessurgical resection

Identifiers

PMID40631006
PMCPMC12230562

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.