ArticleJTCVS open2025
Influences of age and obesity on heart transplant outcomes.
Article in JTCVS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: Obesity and older age have both been identified as risk factors for a worse long-term prognosis after heart transplantation. We sought to determine the 5-year outcomes for heart transplant patients with high-risk body mass index (BMI) >30 (HRB), high-risk age >70 years (HRA), or both (HRAB) as compared with recipients with normal risk (NR) in the modern era. Methods: Records of isolated heart transplants in the United States from 2014 to 2023 were obtained for adults older than 18 years. BMI and age cut-off was identified on spline analysis. Survival curves were built for overall survival using a Kaplan-Meier method, with a log-rank test used to test for differences between groups. Risk adjusted Cox regression was performed on variables potentially influencing overall survival. Results: Between 2014 and 2023, there were 15,839 NR; 869 HRA; 8187 HRB; and 202 HRAB patients. There was a significant difference in overall survival by Kaplan-Meier evaluation between the 4 groups, with worse survival in the high-risk groups ( Conclusions: Overall survival is worse in recipients in the HRA, HRB, or HRAB groups than in recipients in the NR group but similar between patients with isolated BMI >30 or age >70 years. Patients with both increased BMI >30 and age >70 years had the worst overall survival. However, the 5-year survival even for HRAB suggests the value of transplantation even if patients are at high risk.
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