ArticleJTCVS open2025
Does grade matter? Evaluation of histologic grade in patients with stage 1 non-small cell lung cancer using the National Cancer Database.
Article in JTCVS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- An explainable attention-gated stacking ensemble model for predicting survival in non-small cell lung cancer: development and validation.Journal of thoracic disease · 2026Article
- The Association Between Neutrophil-to-Lymphocyte Ratio and Histological Tumor Differentiation in Solid Malignancies: A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Reply: Let's talk about our grade.JTCVS open · 2025Article
- Grades and lung cancer prognostication.JTCVS open · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In the United States, histologic grade in non-small cell lung cancer (NSCLC) is not part of the TNM stage classification. We hypothesize that histologic grade may impact prognosis. Methods: The National Cancer Database (NCDB) for NSCLC was used to identify all pathological stage 1 cancer patients who underwent definitive surgery between 2013 and 2020. Three groups were created using histologic grade for both adenocarcinoma and squamous cell carcinoma: well-differentiated (G1), moderately differentiated (G2), and poorly/undifferentiated (G3). Results: The study cohort comprised 37,727 adenocarcinoma patients (10,784 G1, 18,647 G2, 8476 G3) and 17,697 squamous cell carcinoma patients (601 G1, 10,002 G2, 7904 G3) patients who underwent definitive surgical resection for stage 1 cancer. More patients in the G3 adenocarcinoma group had a larger tumor size (18 mm vs 20 mm vs 21 mm; Conclusions: Histologic grade for adenocarcinoma has gained international attention with the new classification scheme according to the International Association for Study of Lung Cancer. Histologic grade, at least in adenocarcinoma, may provide an important prognostic indicator, and further work is needed to tailor treatment for those with high-grade tumors.
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