Evidence map›Paper›PMID 40630998›Full record

ArticleJTCVS open2025

Surgical pathways and risk categories in the management of hypoplastic left heart syndrome and variants.

V Reed LaSala, Halil Beqaj, Sophia Jackman, Edward Buratto, Priyanka Asrani, Michael Fremed, Andrew Goldstone, Oliver Barry, Sabrina Law, Diana Vargas Chaves and 6 more

Abstract read
PubMed Full text at PMC Publisher
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Article in JTCVS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

V Reed LaSalaSection of Pediatric and Congenital Cardiac Surgery, Division of Cardiac, Thoracic, and Vascular Surgery, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Halil BeqajCollege of Physicians and Surgeons, Columbia University, New York, NY.
Sophia JackmanCollege of Physicians and Surgeons, Columbia University, New York, NY.
Edward BurattoSection of Pediatric and Congenital Cardiac Surgery, Division of Cardiac, Thoracic, and Vascular Surgery, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Priyanka AsraniDivision of Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Michael FremedDivision of Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Andrew GoldstoneSection of Pediatric and Congenital Cardiac Surgery, Division of Cardiac, Thoracic, and Vascular Surgery, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Oliver BarryDivision of Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Sabrina LawDivision of Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Diana Vargas ChavesDivision of Neonatology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Tarif ChoudhuryDivision of Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Stéphanie LevasseurDivision of Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Ganga KrishnamurthyDivision of Neonatology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Christopher PetitDivision of Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
Emile BachaSection of Pediatric and Congenital Cardiac Surgery, Division of Cardiac, Thoracic, and Vascular Surgery, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
David KalfaSection of Pediatric and Congenital Cardiac Surgery, Division of Cardiac, Thoracic, and Vascular Surgery, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The distribution of risk factors in neonates with hypoplastic left heart syndrome is heterogeneous, and their impact remains unclear. We describe the risk categories, surgical strategies, and outcomes in this population. Methods: Retrospective chart review was performed for 233 consecutive neonates undergoing surgery for hypoplastic left heart syndrome and variants at a single center in 2006-2023. The criteria for our risk categories were determined by expert consensus, refined based on Cox regression for mortality, and applied retrospectively to a historical cohort. Results: Of the 233 patients with hypoplastic left heart syndrome, 75 (32%) were standard risk, 128 (55%) were intermediate risk, and 30 (13%) were high risk. A total of 212 patients (91%) underwent primary Norwood and 21 patients (9%) underwent hybrid stage 1. Surgical strategy was strongly correlated with risk category, with more hybrid stage 1 performed in higher-risk patients ( Conclusions: The risk categories presented here effectively stratify patients by operative mortality and mortality at last follow-up and are strongly correlated with surgical strategy. These risk categories may pave the way to develop a predictive risk model to guide decision-making for patients with hypoplastic left heart syndrome.

Indexed as

hybridhypoplastic left heart syndromeNorwoodrisk categorysingle ventricle

Identifiers

PMID40630998
PMCPMC12230582

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.