ArticleCampbell systematic reviews2025
PROTOCOL: Association of Antenatal Cytokine Concentrations With Neurodevelopmental Disorders of the Offspring: A Scoping Review.
Article in Campbell systematic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Artificial intelligence support for diagnosis of neurodevelopmental disorders during childhood: an umbrella review.Frontiers in psychiatry · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The aim of this scoping review is to identify and map the available evidence on the association of antenatal cytokine concentrations with neurodevelopmental disorders (NDDs) of the offspring and to inform future research avenues. Introduction: NDDs are a heterogeneous group of conditions with onset in childhood which affect functioning due to altered brain development. NDDs have a multifactorial aetiology with genetic, epigenetic, and environmental factors, including the foetal intrauterine environment. Maternal immune activation (MIA) alters the intrauterine milieu of the developing foetus, and, in animal studies, has been shown to affect the brain cytoarchitecture, neuronal circuitry and glial function of the offspring. One of the mechanisms of MIA is through cytokines that may play a crucial role in affecting foetal neurodevelopment by crossing the placenta and altering cellular programming. Antenatal cytokine concentrations have the potential to be biomarkers for children at risk of NDDs, and treating a maladaptive cytokine response may reduce the risk of NDDs in these children. Therefore, it is important to understand the scope of evidence available on the association of antenatal cytokine concentration with offspring NDDs and identify the research gaps in this field. Inclusion Criteria: The review will consider all primary and grey literature which focuses on the review objective. The review will not be limited by any time period or any language of the sources of evidence. Method: The review will be conducted following the Joanna Briggs Institute (JBI) methodological framework for scoping reviews. Review questions and inclusion criteria will follow the Population, Concept, Context framework. A comprehensive search will be performed in SCOPUS, MEDLINE (Ovid), PsycINFO (Ovid), Web of Science core collection, Embase (Ovid), CINAHL databases and trial registers. Grey literature will be searched in Google Scholar, ProQuest Dissertations & Theses Global, Open Access Theses and Dissertations and library catalogues with the assistance of the librarian. Two independent reviewers will perform title-abstract screening and full-text screening. Eligible studies will be critically appraised using JBI critical appraisal tools. Data from eligible studies will be extracted by two reviewers using pretested data extraction tools. Findings will be presented in a final scoping review with a narrative summary and diagrammatic forms. Significance: The mapped findings and the identified research gaps will guide further research in evaluating antenatal cytokines as an early biomarker of NDDs and the potential for antenatal therapy to reduce the risk of NDDs. Registration: The review protocol is registered in the Open Science Framework (Link: https://osf.io/twsuq).
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.