Evidence map›Paper›PMID 40630972›Full record

ArticlePsychopharmacology bulletin2025

Effects of Valproate on Intracellular Calcium Ion Signaling: Implications for Mechanistic Research.

Steven L Dubovsky, Elsa Daurignac, Sevie Kandefer

Abstract read
In one paragraph

Article in Psychopharmacology bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Steven L DubovskyDubovsky, MD, Department of Psychiatry, University at Buffalo, Buffalo, NY USA.
Elsa DaurignacDaurignac, PhD, Department of Psychiatry, University at Buffalo, Buffalo, NY USA.
Sevie KandeferKandefer, MS, Department of Psychiatry, University at Buffalo, Buffalo, NY USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Hyperactive intracellular calcium ion concentration ([Ca Experimental design: Platelet [Ca Principal observations: Prior to incubation with valproate, platelet [Ca Conclusions: Mixed results of studies of cellular actions of valproate on intracellular calcium signaling may be the results of use of subjects with milder illness and normal baseline signaling. Studies of animals and normal human subjects may be less informative about the potential mechanism of action of any psychotropic medication than studies of patients with sufficient severity of illness and abnormalities in the dimension of cellular function targeted by the medication.

Indexed as

Antimanic AgentsBipolar DisorderCalciumCalcium SignalingValproic AcidAdultBlood PlateletsFemaleHumansMaleMiddle AgedThrombinAntimanic AgentsCalciumThrombinValproic Acidbipolarintracellular calciummood stabilizersecond messengervalproate

Identifiers

PMID40630972
PMCPMC12233937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.