Evidence map›Paper›PMID 40630970›Full record

Trial reportPsychopharmacology bulletin2025

Pilot Trial of SDX/d-MPH Adult ADHD Examining Effects Throughout the Day.

Lenard A Adler, Dayeon Cho, Terry Leon, Mariane Guschwan, Caleb A Massimi, Deepti Anbarasan

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychopharmacology bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lenard A AdlerAdler, MD, Departments of Psychiatry and Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.
Dayeon ChoCho, MA, Departments of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.
Terry LeonLeon, RN, Departments of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.
Mariane GuschwanGuschwan, MD, Departments of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.
Caleb A MassimiMassimi, BA, Departments of Psychiatry, NYU Grossman School of Medicine; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Deepti AnbarasanAnbarasan, MD, Departments of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To examine the effects of Serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) on ADHD symptoms throughout the day in adults with DSM-5 ADHD. Method: This was a 6-week pilot study that included 3 weeks of open label treatment with SDX/d-MPH (39.2/7.8 mg/day to 52.3/10.4 mg/day in clinical titration) after completion of a one-week screening period and a two-week observation period in seventeen adults with ADHD. Two subjects were discontinued from the trial, one for being placebo-responder and another for exhibiting blood pressure lability during the observation period. Of the remaining 15 subjects, one dropped out after one week on 39.2/7.8 mg/day, while all others completed the trial. All fifteen participants were included in the data analyses. Results: There were substantial effects of SDX/d-MPH on all clinical measures, including investigator symptom scores (AISRS); self-report (ASRS) scores, time-sensitive ADHD (TASS) scores throughout the day, impairment (CGI) and executive function scores (BRIEF-A) and measures of medication smoothness (AMSES). SDX/d-MPH was generally well tolerated. Conclusions: This pilot study is the first systematic treatment effect trial data for SDX/d-MPH in adults with DSM-5 ADHD. The data preliminarily supports the clinical efficacy of DSM/d-MPH in adult ADHD and its ability to ameliorate symptoms throughout the day.

Indexed as

Attention Deficit Disorder with HyperactivityCentral Nervous System StimulantsDextroamphetamineMethylphenidateAdultDrug CombinationsFemaleHumansMaleMiddle AgedPilot ProjectsTreatment OutcomeYoung AdultCentral Nervous System StimulantsDextroamphetamineDrug CombinationsMethylphenidateadult ADHDAISRSASRSBRIEF-ACGIserdexmethylphenidateTASS

Identifiers

PMID40630970
PMCPMC12233939

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.