Evidence map›Paper›PMID 40630949›Full record

ArticleFrontiers in immunology2025

Applications and insights from continuous dengue virus infection in a stable cell line.

M Jane Morwitzer, Ying Yi Zheng, Heather Friberg, Jeffrey R Currier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

M Jane MorwitzerDepartment of Virus-Host Interactions, Viral Diseases Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Ying Yi ZhengDepartment of Virus-Host Interactions, Viral Diseases Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Heather FribergDepartment of Virus-Host Interactions, Viral Diseases Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Jeffrey R CurrierDepartment of Virus-Host Interactions, Viral Diseases Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue is caused by the four serotypes of dengue virus (DENV-1-4) and poses a significant global public health challenge, with an estimated 100-400 million infections annually. Severe dengue manifestations, such as Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS), are influenced by immune responses, particularly during secondary infections with different serotypes. Antibody-dependent enhancement (ADE) of DENV infection is a critical mechanism in dengue immunopathogenesis, underscoring the need for comprehensive evaluation of antibody responses. Traditional cell lines used for DENV propagation exhibit variability and present logistical challenges for assessing non-neutralizing antibody functions. Here, we report the establishment of a stable CEM-NK

Indexed as

DengueDengue VirusAntibodies, NeutralizingAntibodies, ViralAntibody-Dependent EnhancementCell Adhesion MoleculesCell LineDC-Specific ICAM-3 Grabbing NonintegrinHumansLectins, C-TypeReceptors, Cell SurfaceSerogroupAntibodies, NeutralizingAntibodies, ViralCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing NonintegrinLectins, C-TypeReceptors, Cell SurfaceCEM.NKRDC-SIGNdenguedengue therapeuticsdengue vaccinesDENVimmunoassayserotype

Identifiers

PMID40630949
PMCPMC12234473

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.