ReviewInternational journal of nanomedicine2025
Designing Multifunctional Microneedles in Biomedical Engineering: Materials, Methods, and Applications.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- A Portable and Dual-Button Microneedle Device Enables Intelligent Multimodal Laser Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Research advances on protein-based microneedles for treatment of skin diseases: A review.Materials today. Bio · 2026Review
- Microneedle Strategies for Diabetic Wound Management: A Comprehensive Review of Materials, Mechanisms, and Therapeutic Outcomes.Materials today. Advances · 2026Article
- 3D-Printed Microneedle Patch for the Treatment of Melanoma via Synergistic Chemotherapy and Photothermal Therapy.ACS applied bio materials · 2026Article
- Microneedle Technologies for Drug Delivery: Innovations, Applications, and Commercial Challenges.Micromachines · 2026Review
- Bio-RegNet: A Meta-Homeostatic Bayesian Neural Network Framework Integrating Treg-Inspired Immunoregulation and Autophagic Optimization for Adaptive Community Detection and Stable Intelligence.Biomimetics (Basel, Switzerland) · 2026Article
- Microneedle-based transdermal delivery systems for metabolic bone diseases: advances, challenges, and future perspectives.Frontiers in bioengineering and biotechnology · 2026Review
- Systematic Development and Characterization of Enzyme-Free, Borax-Crosslinked Microneedles for Glucose-Responsive Insulin Delivery and In Vivo Glycemic Mitigation.Pharmaceutics · 2025Article
- Extracellular vesicles in chronic wound therapy: engineering strategies and advanced delivery systems for enhanced regeneration.Materials today. Bio · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review focuses on the emerging technology of multifunctional microneedles (MNs) within the biomedical engineering (BME) field, highlighting their potential in drug delivery, diagnostics, and therapeutics. Previous studies have explored MNs in various applications; however, their diverse functionalities across different material types and advanced application domains have been rarely comprehensively explored. This review bridges this gap by providing insights into the application of MNs in materials science, drug delivery, diagnostic monitoring, and tissue engineering. The unique properties and skin effects of various inorganic (eg, silicon, metals) and organic materials (eg, polysaccharides, polymers, proteins) used in MNs are examined. The analysis emphasizes the advantages of different MN materials, ie, their biocompatibility, degradation rates, and application specificity. In addition, the preparation processes and application scenarios of each MN type, such as minimally invasive drug delivery in transdermal applications and their benefits in tissue engineering for promoting repair, regeneration, and precise delivery of cells and growth factors in tissues like skin, cartilage, muscle, bone, and nerves, are discussed. Furthermore, this review explores the innovative use of MNs in brain-computer interfaces-an area not yet thoroughly examined. This novel application offers significant opportunities in neuroscience and clinical practice. Overall, this review provides valuable insights into the current research landscape and unexplored areas of MNs, contributing to future advancements in BME.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.