Evidence map›Paper›PMID 40630934›Full record

ArticleOpen forum infectious diseases2025

The Burden of Neonatal Invasive Candidiasis in Low- and Middle-income Countries: A Systematic Review and Meta-analysis.

Daniel Hsiang-Te Tsai, Ian Chang-Yen Wu, Ling-Fang Chang, Marie Jen-Huey Lu, Brishti Debnath, Nelesh P Govender, Mike Sharland, Adilia Warris, Yingfen Hsia, Laura Ferreras-Antolin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel Hsiang-Te TsaiCentre for Neonatal and Paediatric Infection, City St. George's, University of London, London, UK.ORCID https://orcid.org/0000-0003-2841-0338
Ian Chang-Yen WuCentre for Neonatal and Paediatric Infection, City St. George's, University of London, London, UK.ORCID https://orcid.org/0009-0006-4248-4594
Ling-Fang ChangInstitute of Public Health, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan.
Marie Jen-Huey LuDepartment of Pharmacy, Colleage of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID https://orcid.org/0009-0008-2120-683X
Brishti DebnathCentre for Neonatal and Paediatric Infection, City St. George's, University of London, London, UK.
Nelesh P GovenderWits Mycology Division, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-7869-9462
Mike SharlandCentre for Neonatal and Paediatric Infection, City St. George's, University of London, London, UK.ORCID https://orcid.org/0000-0001-8626-8291
Adilia WarrisMedical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK.ORCID https://orcid.org/0000-0001-6586-3358
Yingfen HsiaCentre for Neonatal and Paediatric Infection, City St. George's, University of London, London, UK.ORCID https://orcid.org/0000-0002-7955-852X
Laura Ferreras-AntolinCentre for Neonatal and Paediatric Infection, City St. George's, University of London, London, UK.ORCID https://orcid.org/0000-0003-2871-1747

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Invasive Methods: We conducted a systematic literature review and meta-analyses of all eligible studies in 17 databases published from inception until April 2022 focusing on microbiologically confirmed NIC in LMICs. Findings: A total of 257 articles were included, with 10 994 NIC cases from 27 LMICs. The overall incidence rate was 2.6% (95% confidence interval [CI], 2.2-3.0). Regional disparities were evident, with South-East Asia reporting the highest incidence rate (6.3%; 95% CI, 3.2-10.3). The mean gestational age and birth weight were 31.4 weeks (standard deviation, 3.3) and 1530 g (standard deviation, 644.6), respectively. Among 10 087 included isolates, the predominant species was Conclusions: A higher NIC incidence rate and CFR in LMICs is noted compared to high-income countries, although infected babies were less premature with a higher birth weight. The proportion of fluconazole-resistant isolates was high. Prevention and treatment strategies for NIC need to be targeted to LMIC settings.

Indexed as

candidemiacase fatality rateincidencelow- and middle-income countriesneonatal invasive candidiasis

Identifiers

PMID40630934
PMCPMC12236162

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.