ArticleFrontiers in neurology2025
Impact of vitamin D supplementation on cognitive impairment in elderly individuals with hypertension.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Older adults frequently experience vitamin D deficiency, which has been linked to both cognitive decline and hypertension. However, evidence on whether correcting vitamin D insufficiency can improve recognition memory and blood pressure (BP) control in this population remains inconclusive. Objective: To evaluate the association between vitamin D supplementation and improvements in cognitive function and BP among older adults with hypertension and mild cognitive deficits. Methods: We conducted a retrospective review of patient records from individuals aged ≥65 years who had documented hypertension, baseline 25-hydroxyvitamin D (25(OH)D) levels < 30 ng/mL, and mild cognitive impairment (Montreal Cognitive Assessment [MoCA] < 26) or subjective cognitive complaints. Patients were categorized into two groups based on recorded vitamin D supplementation (≥5,000 IU/day for ≥6 months vs. no or minimal supplementation). Recognition memory, global cognition (MoCA), systolic and diastolic BP, and serum 25(OH)D levels were compared between groups. Results: Among 153 eligible records, those in the Supplemented group showed greater gains in recognition memory (+3.1 ± 2.4 vs. +1.2 ± 2.0 points; Conclusions: In this retrospective cohort, vitamin D supplementation was associated with notable improvements in recognition memory, global cognition, and systolic BP among older adults with hypertension and mild cognitive deficits. These findings highlight the potential clinical benefits of correcting vitamin D insufficiency in this high-risk population, warranting further investigation in prospective trials.
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