Evidence map›Paper›PMID 40630867›Full record

ArticleJournal of applied polymer science2025

Synthesis and Characterization of Polymer-Drug Conjugates by Strain-Promoted Azide-Alkyne Cycloaddition-Mediated Polymerization.

Omotola D Gbadegesin, Simeon K Adesina

Abstract read
In one paragraph

Article in Journal of applied polymer science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Omotola D GbadegesinDepartment of Pharmaceutical Sciences, Howard University, Washington DC, USA.ORCID 0000-0003-0733-5332
Simeon K AdesinaDepartment of Pharmaceutical Sciences, Howard University, Washington DC, USA.

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
NCI NIH HHS 75N91019D00024
6 · The paper itself

Abstract

Polymer-drug conjugates (PDCs) modify the biodistribution of small-molecule anticancer agents to prevent undesired off-target adverse effects. Here, we report the preparation of two PDCs by strain-promoted [3 + 2] azide-alkyne cycloaddition-mediated step-growth polymerization. This method does not require the use of a catalyst or high temperatures and it allows the rapid synthesis of high molecular-weight PDCs containing gemcitabine (M

Identifiers

PMID40630867
PMCPMC12233213

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.