Evidence map›Paper›PMID 40630812›Full record

ArticleJournal of tropical medicine2025

Mahmoud A A Ibrahim, Alaa M A Hassan, Alaa H M Abdelrahman, Gamal A H Mekhemer, Peter A Sidhom, Shaban R M Sayed, Ashraf M M Abdelbacki, Mohamed-Elamir F Hegazy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of tropical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mahmoud A A IbrahimComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minya 61519, Egypt.ORCID https://orcid.org/0000-0003-4819-2040
Alaa M A HassanComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minya 61519, Egypt.ORCID https://orcid.org/0009-0000-1606-1420
Alaa H M AbdelrahmanComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minya 61519, Egypt.ORCID https://orcid.org/0000-0003-3527-0126
Gamal A H MekhemerComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minya 61519, Egypt.ORCID https://orcid.org/0000-0003-2474-076X
Peter A SidhomDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt.ORCID https://orcid.org/0000-0003-2579-6351
Shaban R M SayedDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.ORCID https://orcid.org/0009-0008-9017-6021
Ashraf M M AbdelbackiDeanship of Skills Development, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.ORCID https://orcid.org/0000-0002-7078-7019
Mohamed-Elamir F HegazyDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany.ORCID https://orcid.org/0000-0002-0343-4969

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epstein-Barr nuclear antigen 1 (EBNA1) is an attractive therapeutic target for identifying pharmaceutical drug molecules to fight Epstein-Barr virus (EBV) contagion because of its key function in viral reproduction. To find potent EBNA1 inhibitors, the Naturally Occurring Plant-based Anticancer Compound-Activity-Target (NPACT) database, including > 1500 compounds, was filtered utilizing computational approaches. The efficiency of the docking technique used to anticipate the inhibitor-EBNA1 binding pose was initially evaluated based on obtainable experimental data. Upon the computed docking scores, molecular dynamics simulations (MDSs) were executed for the most superior NPACT compounds bound to EBNA1, accompanied by binding affinity estimations utilizing the MM/GBSA approach. According to binding affinity computations over 200 ns MDS, bitucarpin A demonstrated stronger Δ

Indexed as

DFT calculationsEBNA1EBV infectionmolecular dynamics simulationsNPACT database

Identifiers

PMID40630812
PMCPMC12237558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.