Evidence map›Paper›PMID 40630790›Full record

ArticleActa histochemica et cytochemica2025

PRP and Cotton-Like β-TCP/PLGA Fibers Enhance Bone Repair in Osteoporotic Vertebral Defects via Macrophage Modulation in Rats.

Yuichi Shimizu, Masateru Nagae, Hitoshi Tonomura, Hidenobu Ishibashi, Nobuaki Takeura, Takahiro Morita, Munehiro Sakata, Shunji Yamada, Masaki Tanaka, Kenji Takahashi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta histochemica et cytochemica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuichi ShimizuDepartment of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajicho Kamigyo-ku, Kyoto 602-8566, Japan.
Masateru NagaeDepartment of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajicho Kamigyo-ku, Kyoto 602-8566, Japan.
Hitoshi TonomuraDepartment of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajicho Kamigyo-ku, Kyoto 602-8566, Japan.
Hidenobu IshibashiDepartment of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajicho Kamigyo-ku, Kyoto 602-8566, Japan.
Nobuaki TakeuraDepartment of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajicho Kamigyo-ku, Kyoto 602-8566, Japan.
Takahiro MoritaDepartment of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajicho Kamigyo-ku, Kyoto 602-8566, Japan.
Munehiro SakataDepartment of Orthopedic Surgery, Japanese Red Cross Kyoto Daini Hospital, 355-5 Haruobicho Kamigyo-ku, Kyoto 602-8062, Japan.
Shunji YamadaDepartment of Anatomy and Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajicho, Kamigyo-ku, Kyoto 602-8566, Japan.
Masaki TanakaDepartment of Anatomy and Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajicho, Kamigyo-ku, Kyoto 602-8566, Japan.
Kenji TakahashiDepartment of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajicho Kamigyo-ku, Kyoto 602-8566, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study assessed the effectiveness of a combination of platelet-rich plasma (PRP) and β-tricalcium phosphate/polylactic-co-glycolic acid (β-TCP/PLGA) fibers in the treatment of osteoporotic vertebral defects in rats. Seventy-two female Sprague-Dawley rats subjected to ovariectomy to induce osteoporosis were divided into three groups to receive different treatments for critical bone defects created in the lumbar vertebrae. The PRP group received β-TCP/PLGA fibers infused with PRP, the control group received no material, and the other group received the same fibers infused with phosphate-buffered saline (PBS). Over a period of 12 weeks, bone regeneration, macrophage differentiation, and inflammatory responses were evaluated histologically. Compared to the PBS group, the PRP-treated group demonstrated significantly enhanced early stage bone formation, increased expression of osteogenic markers, and a favorable shift in macrophage activity from the M1 inflammatory phenotype to the M2 healing phenotype. These outcomes suggest that the combination of PRP and β-TCP/PLGA fibers not only effectively promotes bone repair under osteoporotic conditions but also modulates the immune response to facilitate better healing, indicating its potential as a beneficial surgical intervention for osteoporotic vertebral fractures.

Indexed as

bone regenerationcotton-like β-TCP/PLGA fibermacrophageosteoporotic vertebral fractureplatelet-rich plasma

Identifiers

PMID40630790
PMCPMC12229782

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.