Preferences of Patients With cTTP and Other Chronic Conditions for At-Home Prophylactic Infusions: A Discrete Choice Experiment.

Gaining an understanding of patient preferences regarding treatment administration can help inform approaches to patient care. A discrete choice experiment survey comprising of 7 attributes (treatment environment, convenience, travel times, waiting times, interactions with patients, interactions with healthcare providers, and concerns about complications) was used to assess the stated preferences of patients with chronic conditions, including congenital thrombotic thrombocytopenic purpura (cTTP), for receiving intravenous prophylactic infusions administered at home versus in an outpatient setting. The survey also contained a time trade-off exercise. In total, 307 survey responses were included in the analyses, of which 25 were from patients with cTTP. An overall preference for receiving infusions at home was reported by 137 patients (44.6%), and a high proportion of patients (n = 187, 60.9%) were willing to trade at least 12 months of their lives to receive treatment at home. Patients considered being comfortable with the treatment environment to be the most important attribute. These findings provide insights into the importance of the treatment setting preferences of patients with chronic conditions receiving prophylactic infusions.