Evidence map›Paper›PMID 40630709›Full record

ArticleOncology letters2025

Differential extracellular matrix proteomic signatures in colorectal tumors from Appalachian and non-Appalachian patients.

Alexander T Sougiannis, Harrison B Taylor, Stephen C Zambrzycki, Lindsey Conroy, Rachel Strubler, Christin Edge, Richard R Drake, Kristin Wallace, Derek Allison, Eun Lee and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexander T SougiannisCollege of Medicine, Medical University of South Carolina, Charleston, SC 29403, USA.
Harrison B TaylorDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29403, USA.
Stephen C ZambrzyckiDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29403, USA.
Lindsey ConroyDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40506, USA.
Rachel StrublerDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29403, USA.
Christin EdgeDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29403, USA.
Richard R DrakeDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29403, USA.
Kristin WallaceDepartment of Public Health Services, College of Medicine, Medical University of South Carolina, Charleston, SC 29403, USA.
Derek AllisonDepartment of Pathology and Laboratory Medicine, Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA.
Eun LeeDepartment of Pathology and Laboratory Medicine, Markey Cancer Center, University of Kentucky, Lexington, KY 40506, USA.
Ramon C SunDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40506, USA.
Peggi M AngelDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29403, USA.

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Jennifer F Rogers · 2013 to 2026
$38.3M
NCI NIH HHS P30 CA177558
6 · The paper itself

Abstract

Emerging evidence reports that regulation of the extracellular matrix influences the progression of colorectal cancer (CRC). The present study investigated regulation of the extracellular matrix proteome in colorectal malignancy within a high-risk Appalachian population compared with non-Appalachian populations. A targeted mass spectrometry imaging proteomic method directed at collagen regulation was used. Tissue microarrays (TMAs) comprising of matched CRC with adjacent normal to tumor (NAT) from 45 patients were constructed into 86 samples to evaluate the extracellular matrix proteome (ECM). A total of five specific peaks were discovered to differ between NAT and tumor with high sensitivity and specificity by receiver operating characteristic (AUROC) ≥0.7, Wilson/Brown P<0.0002. Evaluation of patient TMA cores showed increased levels of combined ECM peptides in advanced stage Appalachian CRC (III + IV) compared with early staged CRC (I + II) (AUROC 0.8595; 95% confidence interval, 0.8190-0.8999; Wilson/Brown P<1.0×10

Indexed as

cancercollagencolorectal cancerextracellular matriximagingmass spectrometry imagingspatial proteomics

Identifiers

PMID40630709
PMCPMC12235701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.