ArticleFrontiers in cellular and infection microbiology2025
Predictive value of blood routine-derived inflammation indexes for varicella-zoster virus meningitis in patients with acute herpes zoster.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The Clinical Utility of Serum Biomarkers in the Differentiation and Prognostic Assessment of Viral Meningitis.Pathogens (Basel, Switzerland) · 2026Article
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Abstract
Background: Blood routine-derived inflammation indexes have been studied in many diseases. However, their roles in varicella-zoster virus (VZV)-related central nervous system (CNS) infection diseases are unclear. This study analyzed the value of blood routine-derived inflammatory indexes in the diagnosis and prognosis of VZV meningitis in patients with acute herpes zoster (HZ). Methods: A total of 31 cases of VZV meningitis were selected as the research subjects, with 64 cases of acute HZ admitted to our hospital during the same period as the control group. The blood routine markers and blood routine-derived inflammatory indexes were compared between the two groups. Univariate analysis, logistic regression, and receiver operating characteristic (ROC) curve analysis were used to evaluate the correlation between the levels of each inflammatory marker and the occurrence of VZV meningitis, as well as to evaluate the relationship between the inflammatory markers and the prognosis of VZV meningitis at discharge. Results: Compared with those in the HZ group, the patients in the VZV meningitis group showed significantly increased platelet-to-lymphocyte ratios (PLRs), neutrophil-to-lymphocyte ratios (NLRs), and systemic immune-inflammation index (SII) scores ( Conclusion: The PLR, as a potential inflammatory index, may have certain clinical value in predicting the occurrence and prognosis of VZV meningitis.
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