ArticleEClinicalMedicine2025
Criteria for osteoporosis diagnosis: a systematic review and meta-analysis of osteoporosis diagnostic studies with DXA and QCT.
Article in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Artificial intelligence for opportunistic screening of osteoporosis across multiple imaging modalities: a systematic review.Frontiers in medicine · 2026Pooled it
- Intramuscular fat infiltration is associated with higher vertebral void space burden and lower volumetric bone mineral density in older adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Risk Prediction Models for New Vertebral Fracture After Vertebral Augmentation in Elderly Patients with Osteoporotic Vertebral Compression Fractures: A Systematic Review.Healthcare (Basel, Switzerland) · 2026Review
- Observational
- Radiation dose has no significant impact on CT-based bone mineral density measurements in a large-animal model.Scientific reports · 2026Article
- Development and validation of an osteoporosis risk-assessment model for Chinese older adults: a large-scale retrospective study.BMC geriatrics · 2026Article
- Advancing diagnostic equity through artificial intelligence chest radiograph screening for osteoporosis in Asian populations.NPJ digital medicine · 2026Article
- Machine learning model integrating oral microbiota and clinical features for predicting osteoporosis and bone loss in high-altitude populations.BMC microbiology · 2026Article
- Prevalence and regional distribution of osteoporosis in adults aged 75 years and older: a quantitative computed tomography-based retrospective cross-sectional study.BMC geriatrics · 2026Article
- Periodontitis Leads to Systemic Bone Loss through Neutrophil Reprogramming.Journal of dental research · 2026Article
- Uridine inhibits ROS-mediated osteoclast differentiation and alleviates osteoporosis via modulation of PI3K/Akt-FoxO signaling.Frontiers in immunology · 2026Article
- Sequence-specific radiomics for diagnosis of spinal bone loss.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study aims to evaluate the difference between dual-energy X-ray absorptiometry (DXA) Methods: In this systematic review and meta-analysis (PROSPERO ID: CRD42024599632), we searched Medline, Embase, Scopus, Web of Science, and Cochrane Library databases for studies published from the inception to September 14, 2024. Studies using both QCT and DXA to diagnose OP in the same population were included, and 2 independent reviewers extracted the data by following the PRISMA statement. Pooled odds ratios (ORs) with 95% confidence interval (CI) were estimated using random effects model under heterogeneity. Findings: A total of 19 studies with 3939 cases were included. The meta-analysis results indicated that QCT identified significantly more OP patients than DXA in the same population (OR: 4.91, 95% CI: 3.19-7.54; Interpretation: The incidence of OP examined by QCT is significantly higher than that of DXA. The different prevalence rates obtained from the two diagnostic techniques will inevitably complicate the prevention and treatment of OP, as well as the selection of cases in drug clinical trials. This study highlighted this confusion and aims to motivate relevant organizations or institutions to address this challenge. Funding: There was no funding for this study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.