ArticlemedRxiv : the preprint server for health sciences2025
Interrelations of aortic spring function, cardiovascular disease risk factors, and left ventricular diastolic function: The Framingham Heart Study.
Leroy L Cooper, Brenton R Prescott, Vanessa Xanthakis, Jian Rong, Martin G Larson, Emelia J Benjamin, Naomi M Hamburg, Ramachandran S Vasan, Gary F Mitchell
Abstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Brenton R PrescottBoston University and NHLBI's Framingham Study, Framingham, MA.
Vanessa XanthakisBoston University and NHLBI's Framingham Study, Framingham, MA.
Jian RongSection of Preventive Medicine and Epidemiology, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, MA.
Martin G LarsonSection of Preventive Medicine and Epidemiology, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, MA.
Emelia J BenjaminSection of Preventive Medicine and Epidemiology, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, MA.ORCID 0000-0003-4076-2336 Naomi M HamburgEvans Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.
Ramachandran S VasanSection of Preventive Medicine and Epidemiology, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, MA.
Gary F MitchellCardiovascular Engineering, Inc., Needham, MA.
Funding
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MConProject-006U54HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2018 to 2022
$18.8MCardiac microstructure and the immune-inflammatory response to SARS-CoV-2R01HL131532 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN, LI, DEBIAO · 2016 to 2025
$6.6MClinical and Genetic Correlates of Vascular Function in African Americans: JHSR01HL104184 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI FOX, ERVIN R · 2011 to 2017
$4.5MFramingham: Inflammation, Genes &Cardiovascular DiseaseR01HL076784 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2004 to 2008
$3.9MVentricular Vascular Coupling: Correlates and PrognosisR01HL080124 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2005 to 2009
$3.4MMediators of Systemic Inflammation and Heart Failure Risk in the CommunityR01HL143227 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN · 2019 to 2022
$3.3MCAPSITE: Community Assessment of Pain and Sensitization in the ElderlyR01AG066010 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., EDWARDS, ROBERT R · 2020 to 2025
$3.3MVentricular-vascular coupling in the elderly: lifecourse determinants, trajectories, and prognostic significanceR01HL142983 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHENG, SUSAN, MITCHELL, GARY FRANK · 2019 to 2022
$3.2MEndothelial Cell Health Across the Spectrum of Cardiometabolic DiseaseR01HL168889 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Naomi Miriam Hamburg, Jennifer E Ho · 2023 to 2026
$3.1MAFGen Consortium: Atrial Fibrillation Genomics to Functional AnalysesR01HL128914 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2015 to 2018
$3.1MNHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K01 HL161494NHLBI NIH HHS K24 HL004334NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL060040NHLBI NIH HHS R01 HL070100NHLBI NIH HHS R01 HL071039NHLBI NIH HHS R01 HL076784NHLBI NIH HHS R01 HL077447NHLBI NIH HHS R01 HL080124NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL093328NHLBI NIH HHS R01 HL094898NHLBI NIH HHS R01 HL104184NHLBI NIH HHS R01 HL107385NHLBI NIH HHS R01 HL115391NHLBI NIH HHS R01 HL126136NHLBI NIH HHS R01 HL128914NHLBI NIH HHS R01 HL131532NHLBI NIH HHS R01 HL142983NHLBI NIH HHS R01 HL143227NHLBI NIH HHS R01 HL168889NHLBI NIH HHS R43 HL073551NHLBI NIH HHS R44 HL073551NHLBI NIH HHS U54 HL120163NIA NIH HHS R01 AG028321NIA NIH HHS R01 AG066010NIA NIH HHS RF1 AG079390NIDDK NIH HHS R01 DK080739NIDDK NIH HHS R01 DK082447
6 · The paper itselfAbstract
Background: Energy associated with proximal aortic stretch during systole is recovered as diastolic elastic recoil of the aorta that facilitates left ventricular filling. Impairment of this aortic spring mechanism may contribute to left ventricular diastolic dysfunction. However, cross-sectional and longitudinal inter-relations of cardiovascular disease risk factors, aortic stretch, and left ventricular diastolic function have not been examined. The goal of this study was to assess the cross-sectional and longitudinal associations of cardiovascular disease risk factors and systolic atrioventricular plane displacement (AVPD), a surrogate measure of stretch of the mechanically coupled ascending aorta, with measures of left ventricular diastolic function. Methods: At two examinations (14±1 years apart) in Framingham Heart Study participants (N=7117; mean age 50 years, 55% women), we assessed AVPD and left ventricular diastolic function using echocardiography. We measured systolic AVPD using the integral of the tissue Doppler s' wave. Additionally, we assessed e' (the peak early diastolic tissue velocity of the lateral mitral annulus) and E/e' (the ratio of peak early mitral inflow velocity and e'). Results: In cross-sectional analyses, higher AVPD was associated with higher e' ( Conclusion: The aortic spring function, as assessed via AVPD, may play an important role in maintaining left ventricular diastolic function, with putative effects modified by aortic stiffness, obesity, age, and sex.
Indexed as
aortic springdiastolic functionleft ventricular-arterial couplingmechanical loadvascular hemodynamics
Identifiers
PMID40630593
PMCPMC12236873
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