Evidence map›Paper›PMID 40630588›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Impact of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine on sexually transmitted and reproductive tract infections: results from a randomised trial in Uganda.

Harriet Adrama, Erin J Dela Cruz, Nida Ozarslan, Abel Kakuru, Bakar Odongo, Stephanie L Gaw, Jade Benjamin-Chung, Jimmy Kizza, Miriam Aguti, John Ategeka and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Harriet AdramaInfectious Diseases Research Collaboration, Kampala, Uganda.
Erin J Dela CruzDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Nida OzarslanDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA, USA.
Abel KakuruInfectious Diseases Research Collaboration, Kampala, Uganda.
Bakar OdongoInfectious Diseases Research Collaboration, Kampala, Uganda.
Stephanie L GawDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA, USA.ORCID 0000-0003-0891-6964
Jade Benjamin-ChungDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.ORCID 0000-0003-3631-3132
Jimmy KizzaInfectious Diseases Research Collaboration, Kampala, Uganda.
Miriam AgutiInfectious Diseases Research Collaboration, Kampala, Uganda.
John AtegekaInfectious Diseases Research Collaboration, Kampala, Uganda.
Peter OlwochInfectious Diseases Research Collaboration, Kampala, Uganda.
Miriam NakalembeCollege of Health Sciences, Makerere University, Kampala, Uganda.
Bishop OpiraInfectious Diseases Research Collaboration, Kampala, Uganda.
Tamara D ClarkDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Moses R KamyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Philip J RosenthalDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Grant DorseyDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Michelle E RohInstitute for Global Health Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6268-0801

Funding

BIOLOGY OF INFECTIOUS DISEASES TRAINING PROGRAMT32AI007641 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY · 2000 to 2026
$6.9M
Optimal chemopreventive regimens to prevent malaria and improve birth outcomes in UgandaU01AI141308 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DORSEY, MATTHEW G, ROSENTHAL, PHILIP JON · 2020 to 2024
$6.0M
Mentoring translational researchers in perinatal infectious diseasesK24AI188458 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Stephanie Lina Gaw · 2025 to 2026
$412k
Examining the mechanisms and optimization of malaria chemoprevention strategies to improve birth outcomes in AfricaK99HD111572 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROH, MICHELLE · 2023 to 2024
$246k
NIAID NIH HHS K24 AI188458NIAID NIH HHS T32 AI007641NIAID NIH HHS U01 AI141308NICHD NIH HHS K99 HD111572
6 · The paper itself

Abstract

Background: In sub-Saharan Africa, sexually transmitted and reproductive tract infections (STIs/RTIs) are important, but underdiagnosed risk factors for adverse pregnancy outcomes. Sulfadoxine-pyrimethamine (SP), used for intermittent preventive treatment of malaria in pregnancy (IPTp), may reduce STI/RTI burden due to its antibacterial activity. We assessed the impact of IPTp regimens on STI/RTI prevalence at delivery and associations between these infections and adverse birth outcomes. Methods: We conducted a secondary analysis of a randomized controlled trial comparing monthly IPTp with SP, dihydroartemisinin-piperaquine (DP), or DP+SP among pregnant women in Uganda. Vaginal swabs collected at or near delivery were tested for Results: Among the 2265 participants assessed, IPTp-SP reduced prevalence of Conclusions: Monthly IPTp-SP reduced the prevalence of

Indexed as

bacterial vaginosisChlamydia trachomatisGroup B Streptococcusintermittent preventive treatment in pregnancyNeisseria gonorrhoeaereproductive tract infectionssexually transmitted infectionssulfadoxine-pyrimethamineTrichomonas vaginalis

Identifiers

PMID40630588
PMCPMC12236864

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.