Evidence map›Paper›PMID 40630576›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Etiological basis for chronic pain genetic variation in brain and dorsal root ganglia cell types.

Sylvanus Toikumo, Marc Parisien, Michael J Leone, Chaitanya Srinivasan, Huasheng Yu, Asta Arendt-Tranholm, Úrzula Franco-Enzástiga, Christoph Hofstetter, Michele Curatolo, Wenqin Luo and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Sylvanus ToikumoMental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA 19104, USA.ORCID 0000-0002-6024-0693
Marc ParisienAlan Edwards Centre for Research on Pain, McGill University, Montreal, QC, H3A-0G1, Canada.ORCID 0000-0003-2924-5960
Michael J LeoneDepartment of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Chaitanya SrinivasanDepartment of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Huasheng YuDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Asta Arendt-TranholmCenter for Advanced Pain Studies, Department of Neuroscience, University of Texas at Dallas, Richardson, TX, USA.
Úrzula Franco-EnzástigaCenter for Advanced Pain Studies, Department of Neuroscience, University of Texas at Dallas, Richardson, TX, USA.
Christoph HofstetterDepartment of Neurological Surgery, University of Washington, Seattle WA, USA.
Michele CuratoloDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle WA, USA.
Wenqin LuoDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-2486-807X
Andreas R PfenningDepartment of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0002-3447-9801
Rebecca P SealDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Rachel L KemberMental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA 19104, USA.ORCID 0000-0001-8820-2659
Theodore J PriceCenter for Advanced Pain Studies, Department of Neuroscience, University of Texas at Dallas, Richardson, TX, USA.ORCID 0000-0002-6971-6221
Luda DiatchenkoAlan Edwards Centre for Research on Pain, McGill University, Montreal, QC, H3A-0G1, Canada.
Stephen G WaxmanVeterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Henry R KranzlerMental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA 19104, USA.

Funding

Mechanistic underpinnings of chronic low back painU19NS130608 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI Diana Tavares Ferreira · 2022 to 2026
$13.6M
The Penn Human Precision Pain Center (HPPC): Discovery and Functional Evaluation of Human Primary Somatosensory Neuron Types at Normal and Chronic Pain ConditionsU19NS135528 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Mingyao Li, Wenqin Luo · 2023 to 2026
$11.2M
Radiochemistry CoreP30DA046345 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KRANZLER, HENRY RICHARD, MACH, ROBERT H · 2019 to 2023
$9.4M
Characterizing the phenotypic spectrum associated with genetic liability for alcohol use disorderK01AA028292 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI KEMBER, RACHEL LORRAINE · 2021 to 2024
$505k
Cell-type specific molecular and functional analyses to target dorsal horn pain circuitry in mice and non-human primatesR56NS133364 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PFENNING, ANDREAS ROBERT, SEAL, REBECCA P · 2023 to 2023
$499k
Harnessing the genetics of chronic pain to inform the development of non-additive analgesic medicationsK99DA060906 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI TOIKUMO, SYLVANUS · 2025 to 2025
$118k
Identifying and targeting neural subpopulations of the spinal cord that mediate chronic pain via cell-type-specific cis-regulatory elementsF31NS134318 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI LEONE, MICHAEL · 2024 to 2025
$75k
BLRD VA I01 BX003341NIAAA NIH HHS K01 AA028292NIDA NIH HHS K99 DA060906NIDA NIH HHS P30 DA046345NINDS NIH HHS F31 NS134318NINDS NIH HHS R56 NS133364NINDS NIH HHS U19 NS130608NINDS NIH HHS U19 NS135528RRD VA I50 RX002999
6 · The paper itself

Abstract

Chronic pain is a complex clinical problem comprising multiple conditions that may share a common genetic profile. Genome-wide association studies (GWAS) have identified many risk loci whose cell-type context remains unclear. Here, we integrated GWAS data on chronic pain (

Identifiers

PMID40630576
PMCPMC12236857

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.