Impact of molecular structures of lauroyl glycine derivatives on foaming properties.

Introduction: This investigation systematically elucidates the foam dynamics and consumer perception correlations within amino-acid-derived surfactant-mixedcomponent systems. Methods: pH-gradient experiments (5.5-10) combined with dynamic foam analysis were employed to quantify foam nucleation kinetics. Molecular dynamics simulations analyzed intermolecular interactions, while lipid resistance evaluations measured cleaning efficiency. Results: SLG-CAB blends accelerated foam nucleation from 35 s to 20 s/100 mL (pH=8.5), outperforming commercial benchmarks (<5 s initial formation) with statistical significance. Robust hydrogen bonds between CAB's ammonium protons and SLG's carboxamide oxygen (bond length: 1.901 Å) achieved thermodynamic stabilization (ΔE = -53.04 kcal/mol), enhancing film stability (Tfls 50% > 5 min). SLG-CAB generated monodisperse bubbles (diameter ≈95 μm), imparting "velvety" sensory properties, with 74.74% lipid cleaning efficiency at pH 7-8 (synergistic coefficient βs = -2.822). Discussion: The SLG-CAB system demonstrates synergistic foam enhancement and lipid resistance, enabling "prolonged creaminess" in cleansing applications. Bridging cosmetic applications (facial cleansers, body washes) with surfactant engineering principles, this work establishes phase behavior-guided formulation strategies for personal care products.