ArticleResearch square2025
Enkephalinergic Neurons in Barrington's Nucleus Gate Sex-Specific Control of Micturition.
Nataliya Klymko, Andrea M Sartori, Mihoko Leon, Cassandra N Seifert, Richard Lee, John C Mathai, Anne M J Verstegen
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Nataliya KlymkoDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Andrea M SartoriDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-9571-0288 Mihoko LeonDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Cassandra N SeifertDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Richard LeeDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
John C MathaiDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Anne M J VerstegenDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0001-9510-7211 Funding
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2000 to 2019
$31.4MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI HU, FRANK B · 1992 to 2021
$25.0MMapping brainstem control of continenceR01DK113030 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ZEIDEL, MARK L. · 2017 to 2021
$1.9MBladder fullness signaling and the neural control of continenceR01DK125708 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI VERSTEGEN, ANNE ("HANNEKE") · 2020 to 2024
$1.9MSingle cell transcriptome profiling to define cell types in brain nuclei controlling bladder functionP20DK119789 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ZEIDEL, MARK L. · 2018 to 2019
$700kNIDDK NIH HHS P20 DK119789NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK113030NIDDK NIH HHS R01 DK125708
6 · The paper itselfAbstract
Lower urinary tract (LUT) control is a vital physiological function governed by a complex interplay between neural circuits and muscle activity. This regulation depends on brainstem circuits, with Barrington's nucleus (Bar) acting as a central hub. Here, we construct a transcriptional atlas of Bar, uncovering its neuronal diversity and extensively characterize a distinct excitatory population expressing
Indexed as
Barrington’s NucleusBladderExternal urethral sphincterLower urinary tractMicturitionNeural control of LUT functionNeuronalPenkPhysiologyProenkephalinSex-specific behavior
Identifiers
PMID40630540
PMCPMC12236902
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390