Evidence map›Paper›PMID 40630512›Full record

ArticleResearch square2025

Reinfection with a Bacterial Pathogen Augments Heterogeneity in Host Disease Responses.

Jesse Garrett-Larsen, Anna Pérez-Umphrey, Arietta Fleming-Davies, James Adelman, Lauren Childs, Steven Geary, Kate Langwig, Dana Hawley

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jesse Garrett-LarsenVirginia Tech.
Anna Pérez-UmphreyVirginia Tech.
Arietta Fleming-DaviesUniversity of California, San Diego.
James AdelmanUniversity of Memphis.
Lauren ChildsVirginia Tech.
Steven GearyUniversity of Connecticut.
Kate LangwigVirginia Tech.
Dana HawleyVirginia Tech.

Funding

Ecological and evolutionary causes and consequences of host heterogeneity induced by prior exposureR01GM144972 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI HAWLEY, DANA M · 2021 to 2024
$2.0M
NIGMS NIH HHS R01 GM144972
6 · The paper itself

Abstract

Individual responses to infection are often highly heterogeneous within host populations, with key consequences for transmission dynamics and pathogen evolution. Because re-exposure to pathogens is ubiquitous, understanding how priming exposures to a given pathogen alter inter-individual heterogeneity in immune responses and transmission-relevant traits is critical. Recent work in house finches (

Identifiers

PMID40630512
PMCPMC12236904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.