ArticleFrontiers in medicine2025
The correlation between red blood cell distribution width to serum albumin ratio and all-cause mortality in critically ill patients with chronic obstructive pulmonary disease: a retrospective study using the MIMIC-IV database.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Association of red blood cell distribution width to albumin ratio with all-cause and cardiovascular mortality among adults with MASLD.BMC gastroenterology · 2026Article
- Association of red cell distribution width-to-albumin ratio with mortality in adults with low muscle mass: A retrospective cohort study.The Journal of international medical research · 2026Article
- Association between red cell distribution width-to-albumin ratio and In-hospital mortality in patients with acute exacerbation of chronic obstructive pulmonary disease and respiratory failure: a retrospective cohort study.Biomarkers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic obstructive pulmonary disease (COPD) significantly contributes to critical illness and mortality in intensive care units (ICU), yet validated prognostic biomarkers are limited. The red blood cell distribution width to albumin ratio (RAR), which reflects systemic inflammation and nutritional imbalance, has shown predictive value in chronic kidney disease and diabetes. However, its association with mortality in critically ill COPD patients has not been explored. This study investigates the relationship between RAR and all-cause mortality in this high-risk population. Methods: Utilizing the MIMIC-IV database, 3,779 patients admitted to the ICU for the first time and diagnosed with COPD between 2008 and 2019 were included. Patients were categorized into four groups (Q1-Q4) based on the RAR quartiles within 24 h of admission. Kaplan-Meier curves and Cox proportional hazards models were employed to analyze the correlation between RAR and all-cause mortality at 30, 90, 180, and 365 days. The dose-response relationship was assessed using restricted cubic splines (RCS), and subgroup sensitivity analyses were conducted to evaluate the robustness of the results. Results: Patients in the highest RAR group (Q4, 7.18-8.38) exhibited higher baseline inflammation and disease severity. The 30-day and 365-day mortality rates were 31.47 and 36.33%, respectively, significantly higher than those in the Q1 group (6.67 and 8.58%). After multivariate adjustment (age, gender, SOFA/APSIII scores, etc.), the 30-day mortality risk in the Q4 group was 2.13 times greater than that in the Q1 group (HR = 2.13, 95%CI: 1.54-2.99), and the 365-day risk was 2.17 times greater (HR = 2.17, 95%CI: 1.61-2.93). RCS indicated a linear positive correlation between RAR and mortality rates (non-linearity Conclusion: RAR serves as an independent predictor of all-cause mortality in critically ill patients with COPD. As a low-cost and readily available biomarker, this index has the potential to provide new insights for risk stratification of ICU patients. However, further prospective studies are needed to confirm its clinical translation value.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.