Evidence map›Paper›PMID 40630481›Full record

ArticleFrontiers in medicine2025

Changes in the ocular surface and meibomian glands following administration of 0.01 and 0.02% atropine.

Xueyan Li, Yanying Zhu, Haiyan Xie, Yuexin Chen, Yukun Liu, Xiaochen Xu, Jing Wang

Abstract read
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xueyan Li *The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.
Yanying Zhu *The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.
Haiyan XieThe Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.
Yuexin ChenThe Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.
Yukun LiuThe Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.
Xiaochen XuWuhu City Eye Hospital, Wuhu, China.
Jing WangThe Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To investigate the changes in the ocular surface and meibomian glands following the administration of 0.01 and 0.02% atropine. Setting: The Second Affiliated Hospital of Anhui Medical University, Anhui, China. Methods: In this randomized controlled study, the 0.01% group (18 patients, 36 eyes) and the 0.02% group (15 patients, 30 eyes) underwent assessments using the Ocular Surface Disease Index (OSDI), Visual Analogue scale (VAS), tear meniscus height (TMH), first noninvasive tear film breakup time (fNIBUT), and average noninvasive tear film breakup time (avNIBUT) at baseline (before administration) and at 1, 3, 6, and 12 months post-treatment. The meibomian glands of both the upper (U) and lower (L) eyelids were evaluated using Meibomian Gland Bio-image Analyzer, measuring parameters such as average gland diameter (avGD), average gland length (avGL), average gland area (avGA), deformation coefficient (DC), and gland visibility score (VS). Results: There were no statistically significant differences in any of the parameters within the 0.01% group (all Conclusion: 0.01% atropine had no significant impact. 0.02% atropine eye drops affected the lipid secretion of meibomian glands, tear meniscus height and subjective discomfort.

Indexed as

childrenlow-concentration atropinemeibomian gland bio-image analyzermyopiaocular surface

Identifiers

PMID40630481
PMCPMC12234563

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.