Evidence map›Paper›PMID 40630379›Full record

ArticleERJ open research2025

Associations of metabolic syndrome with lung function decline and clinical respiratory outcomes: the NHLBI Pooled Cohort Study.

Yuni Choi, Pallavi P Balte, David R Jacobs, Stephanie J London, Ana Navas-Acien, Anne B Newman, George T O'Connor, Joseph E Schwartz, Benjamin M Smith, Wendy B White and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuni ChoiColumbia University Medical Center, New York, NY, USA.
Pallavi P BalteColumbia University Medical Center, New York, NY, USA.
David R JacobsUniversity of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-7232-0543
Stephanie J LondonNIH/NIEHS, Research Triangle Park, NC, USA.ORCID https://orcid.org/0000-0003-4911-5290
Ana Navas-AcienColumbia University Medical Center, New York, NY, USA.
Anne B NewmanUniversity of Pittsburgh, Pittsburgh, PA, USA.
George T O'ConnorBoston University, Boston, MA, USA.
Joseph E SchwartzColumbia University Medical Center, New York, NY, USA.
Benjamin M SmithColumbia University, New York, NY, USA.
Wendy B WhiteTougaloo College, Tougaloo, MS, USA.
Sachin YendeUniversity of Pittsburgh, Pittsburgh, PA, USA.
Elizabeth C OelsnerColumbia University Medical Center, New York, NY, USA.

Funding

Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
Infrastructure for mentored access to CHS data and specimensR01HL172803 · NHLBI · UNIVERSITY OF WASHINGTON · PI James S Floyd, Michelle Christina Odden · 2025 to 2026
$2.7M
Airway Tree Subtyping on Large Cohorts of CT Images for COPD RiskR01HL155816 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAINE, ANDREW FRANCIS, SMITH, BENJAMIN M. · 2021 to 2024
$2.4M
Hypercoagulability and Chronic Lung Disease in Older AdultsK23HL130627 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OELSNER, ELIZABETH · 2016 to 2019
$686k
Albuminuria and incident chronic lung disease exacerbations in five population-based cohortsR21HL129924 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OELSNER, ELIZABETH · 2015 to 2016
$440k
HDL cholesterol and chronic lower respiratory disease events in five cohortsR21HL121457 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARR, R GRAHAM · 2013 to 2014
$232k
NHLBI NIH HHS K23 HL130627NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL155816NHLBI NIH HHS R01 HL172803NHLBI NIH HHS R21 HL121457NHLBI NIH HHS R21 HL129924
6 · The paper itself

Abstract

Background: Whether metabolic syndrome (MetS) increases the risk of chronic lung diseases remains uncertain. We aimed to test whether MetS was associated with lung function and clinical respiratory outcomes. Methods: Data were harmonised from six US general population-based prospective cohorts. Participants with baseline airflow limitation (forced expiratory volume in 1 s (FEV Results: Of 15 728 participants (mean age 49.6 years, 57.6% female, 68.6% White, 27.0% Black), 4422 (28.1%) had MetS. In fully adjusted models that included body weight, MetS was associated with greater rate of FVC decline (-0.89 mL·year Conclusions: MetS was associated with accelerated FVC decline and incident restriction, but not incident obstruction, in healthy adults.

Identifiers

PMID40630379
PMCPMC12230753

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.