Evidence map›Paper›PMID 40630297›Full record

ArticleKidney international reports2025

Gut Microbiome as a Risk Factor for Future CKD.

Tapio Hellman, Li-Fang Yeo, Joonatan Palmu, Aki Havulinna, Pekka Jousilahti, Ville Laitinen, Katariina Pärnänen, Veikko Salomaa, Leo Lahti, Rob Knight and 1 more

Abstract read
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Gut Microbiota Metabolites and the Development of CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tapio HellmanKidney Center, Turku University Hospital and University of Turku, Turku, Finland.
Li-Fang YeoDivision of Medicine, University of Turku, Turku, Finland.
Joonatan PalmuDivision of Medicine, University of Turku, Turku, Finland.
Aki HavulinnaDepartment of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland.
Pekka JousilahtiDepartment of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland.
Ville LaitinenDepartment of Computing, University of Turku, Turku, Finland.
Katariina PärnänenDepartment of Computing, University of Turku, Turku, Finland.
Veikko SalomaaDepartment of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland.
Leo LahtiDepartment of Computing, University of Turku, Turku, Finland.
Rob KnightDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Teemu NiiranenDivision of Medicine, University of Turku, Turku, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Gut microbiome has been linked with chronic kidney disease (CKD) in several small cross-sectional studies. However, the relationship between baseline gut microbiome and long-term incident CKD remains unknown. Methods: We performed fecal sampling and measured serum creatinine (SCR) ( Results: The mean age of the participants was 49.5 ± 12.9 years and 45.8% were men. During a median follow-up of 18.6 years, 108 participants developed incident CKD. In prospective analyses, increased baseline gut microbiome alpha diversity was associated with lower risk of incident CKD (hazard ratio per 1 SD: 0.84; 95% confidence interval [CI]: 0.71-0.99; Conclusion: Our results suggest that decreased gut microbial diversity may be related to risk of future CKD and that a potential link between the

Indexed as

chronic kidney diseaseclinical studymicrobiologyproteinuria

Identifiers

PMID40630297
PMCPMC12231020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.