Evidence map›Paper›PMID 40630283›Full record

ArticleKidney international reports2025

Gut Microbiome Diversity and Uric Acid in Serum and Urine.

Cecilie Ness, Dmitri Svistounov, Marit D Solbu, Natalia Petrenya, Neoma Boardman, Kirsti Ytrehus, Trond G Jenssen, Andrew Holmes, Stephen J Simpson, Svetlana N Zykova

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In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cecilie NessDepartment of Medical Biology, UiT - The Arctic University of Norway, Tromsø, Norway.
Dmitri SvistounovMetabolic and Renal Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT - The Arctic University of Norway, Tromsø, Norway.
Marit D SolbuMetabolic and Renal Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT - The Arctic University of Norway, Tromsø, Norway.
Natalia PetrenyaThe Public Dental Health Service Competence Centre of Northern Norway, Tromsø, Norway.
Neoma BoardmanDepartment of Medical Biology, UiT - The Arctic University of Norway, Tromsø, Norway.
Kirsti YtrehusDepartment of Medical Biology, UiT - The Arctic University of Norway, Tromsø, Norway.
Trond G JenssenDepartment of Transplantation Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway.
Andrew HolmesCharles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia.
Stephen J SimpsonCharles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia.
Svetlana N ZykovaThe Public Dental Health Service Competence Centre of Northern Norway, Tromsø, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: An increasing body of evidence has shown the importance of the gut microbiota in modulating serum uric acid (SUA) levels. In this study, we aimed to determine the association between gut microbiome diversity, diet, SUA, and fractional excretion of uric acid (FEUA) in the kidney. Methods: A cross-sectional study was conducted in 53 adults with normal or elevated SUA and estimated glomerular filtration rate (eGFR) range from 37 to 124 ml/min per 1.73 m Results: Shannon index was negatively associated with SUA after multiple adjustment (β -36.4, 95% CI [-66.2 to -6.7], Conclusion: A higher gut microbial diversity was associated with lower SUA and more efficient elimination of uric acid by the kidneys. There is a need for studies assessing efficacy and safety of interventions on the gut microbiome as a treatment of hyperuricemia.

Indexed as

hyperuricemiakidney functionmicrobiomeuric acid

Identifiers

PMID40630283
PMCPMC12231022

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.