Evidence map›Paper›PMID 40630282›Full record

ArticleKidney international reports2025

Patients With Mild ADPKD by Kidney Imaging but Low Estimated GFR.

Seung Heyck Lee, Mauricio Miranda Cam, Taher Dehkharghanian, Fatemah Nasri, Saima Khowaja, Amirreza Haghighi, Xuewen Song, Korosh Khalili, York Pei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Seung Heyck LeeDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Mauricio Miranda CamDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Taher DehkharghanianDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Fatemah NasriDepartment of Medical Imaging, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Saima KhowajaDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Amirreza HaghighiDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Xuewen SongDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.
Korosh KhaliliDepartment of Medical Imaging, University Health Network and University of Toronto, Toronto, Ontario, Canada.
York PeiDivision of Nephrology, University Health Network and University of Toronto, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: High height-adjusted total kidney volume (HtTKV) and low estimated glomerular filtration rate (eGFR) typically indicate high cystic burden by imaging and low kidney function, respectively, identifying high-risk patients for disease progression in autosomal dominant polycystic kidney disease (ADPKD). Here, we report the prevalence, clinical characteristics, and causes of mild ADPKD in patients using imaging and low eGFR, an ill-defined clinical scenario. Methods: We studied 473 patients with kidney function measurements, Results: Of 473 patients, 55 (12%) displayed a discordant phenotype. Among these patients, 13 (24%) had normal kidney functions by 24-h creatinine clearance (CrCl Conclusion: Mild ADPKD by imaging with low eGFR represents a significant clinical scenario with conflicting prognostic indicators, underscoring the need for delineating underlying causes and providing more appropriate management.

Indexed as

ADPKDbiomarkersCKDpatient-centered carepolycystic kidney diseaserenal function

Identifiers

PMID40630282
PMCPMC12231023

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.