Evidence map›Paper›PMID 40630276›Full record

ArticleKidney international reports2025

Prospective Study of a Point-of-Care Diagnostic Test for Acute Kidney Injury in a South Asian Hospital.

Tejashree S Gopal, Katherine Xu, Yechiel Muller, Jai Radhakrishnan, Vivekanandan Pillai, Jonathan Barasch, Sreejith Parameswaran, Catherine S Forster

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tejashree S GopalDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Katherine XuDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Yechiel MullerDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Jai RadhakrishnanDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Vivekanandan PillaiNephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Jonathan BaraschDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Sreejith ParameswaranNephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Catherine S ForsterDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

Transcriptional Regulation of Urothelial Differentiation During Homeostasis and Repair in Response to Urinary Tract InfectionU54DK104309 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JONATHAN M. BARASCH, ALI G GHARAVI · 2014 to 2026
$17.7M
Structure and mechanism of the protein-capture receptors of the kidney proximal tubuleR01DK124667 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARASCH, JONATHAN M., SHAPIRO, LAWRENCE S · 2020 to 2023
$2.6M
Human Genetic Approach for UTI Points to Novel Immune Defense Cells of the Kidney EpitheliaK01DK135917 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Katherine Xu · 2024 to 2026
$458k
NIDDK NIH HHS K01 DK135917NIDDK NIH HHS R01 DK124667NIDDK NIH HHS U54 DK104309
6 · The paper itself

Abstract

Introduction: Serum creatinine (SCr) is used to diagnose acute kidney injury (AKI) but has limited utility to distinguish volume depletion from tubular injury. Urine neutrophil gelatinase-associated lipocalin (uNGAL) distinguishes these causes of elevated SCr. Methods: We tested a novel point-of-care (POC) dipstick to measure uNGAL at presentation at the emergency medical services department (EMSD) in a tertiary care hospital in Puducherry, India. The primary outcome was a sustained elevation of SCr; the secondary outcome was in-hospital mortality. The study enrolled 396 patients with a mean age of 49.7 years (SD: 16); 36% were female. Sufficient measurements for SCr kinetics were obtained from 229 patients. Owing to inconsistent serial measurements of SCr for some patients, subanalyses were conducted for "strict" and "inclusive" SCr defined subsets, which yielded similar results. Results: Elevated uNGAL (median [interquartile range]: 500 ± 350 ng/ml) in the EMSD indicated sustained increases of SCr (> 48 hours); whereas much lower levels of uNGAL indicated either transient changes (< 48 hours; 150 ± 250 ng/ml) or no elevation of SCr (50 ± 97.5 ng/ml) ( Conclusion: uNGAL dipstick can diagnose kidney damage associated with sustained elevation of SCr and death at patient encounter in the EMSD.

Indexed as

AKIdipstickNGAL

Identifiers

PMID40630276
PMCPMC12231037

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.