ArticleKidney international reports2025
The Role of von Willebrand Factor in the Pathogenesis of C3 Glomerulopathy.
Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
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8 authors.
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Abstract
Introduction: C3 glomerulopathy (C3G) is caused by dysregulation of complement activation. Our previous study found that patients with C3G showed rare variants in von Willebrand factor (vWF). However, the role of vWF in the pathogenesis of C3G is still unclear. Method: Patients with C3G diagnosed using kidney biopsy in Peking University First Hospital from 2012 to 2021 were included in the study. The levels of vWF in plasma, urine, and kidney specimens of patients with C3G were detected using enzyme-linked immunosorbent assay (ELISA) or immunofluorescence, respectively, and their associations with clinicopathological data were analyzed. Results: There were 44 patients with C3G included. The urinary level of vWF-to-creatinine ratio (vWF/Cr) in patients with C3G was associated with the level of serum creatinine (Scr) ( Conclusion: The levels of vWF were associated with disease severity and poor prognosis of patients with C3G.
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