Evidence map›Paper›PMID 40630232›Full record

ArticleChinese chemical letters = Zhongguo hua xue kuai bao2025

The sheet-to-helix transition is a potential gas-phase unfolding pathway for a multidomain protein CRM

Xia Xu, Guiqian Yang, Zhen Zheng, Cody J Wenthur, Jinyu Li, Gongyu Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chinese chemical letters = Zhongguo hua xue kuai bao, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xia XuTianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Science, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China.
Guiqian YangCollege of Chemistry, Fuzhou University, Fuzhou 350002, China.
Zhen ZhengSchool of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
Cody J WenthurSchool of Pharmacy, University of Wisconsin-Madison, Wisconsin 53705, United States.
Jinyu LiCollege of Chemistry, Fuzhou University, Fuzhou 350002, China.
Gongyu LiTianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Science, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China.

Funding

Deconvoluting Polypharmacologic Contributions of Rapidly-Acting AntidepressantsR01MH122742 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI WENTHUR, CODY JAMES · 2020 to 2024
$2.2M
NIMH NIH HHS R01 MH122742
6 · The paper itself

Abstract

Despite the expansive applications of gas-phase unfolding techniques, the molecular mechanism for the solvent-free forced unfolding pathway which substrate multidomain proteins usually adopt remains elusive at the secondary structure level. Herein, upon carefully selecting CRM

Identifiers

PMID40630232
PMCPMC12233276

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.