ArticleExperimental and therapeutic medicine2025
Role and mechanism of RPA1 in the development and progression of glioma.
Article in Experimental and therapeutic medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Glioma is a highly malignant primary tumor of the central nervous system, characterized by highly invasive behavior and a high recurrence rate. The current treatment options for gliomaoften have unsatisfactory outcomes. Replication protein A1 (RPA1), a component of the RPA heterotrimer, has been identified as a potential oncogene implicated in the development and clinical prognosis of various types of solid tumors, including liver cancer, nasopharyngeal carcinoma and gastrointestinal cancer. However, studies on the associations between RPA1 expression and glioma cell proliferation or patient prognosis are limited, and the underlying mechanisms remain unclear. The aim of the present study was to explore the expression of RPA1 in glioma and its clinical relevance in the clinicopathology and prognosis of glioma. In addition, the biological functions and signal transduction pathways mediated by RPA1 were predicted using bioinformatics analysis to provide basic theoretical support for further mechanistic research and
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