ArticleLaryngoscope investigative otolaryngology2025
Induced Chronic Rhinosinusitis in Rats Leads to Secondary Changes in Sinonasal Microbiota.
Article in Laryngoscope investigative otolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Induced Chronic Rhinosinusitis in Rats Leads to Secondary Changes in Sinonasal Microbiota.Laryngoscope investigative otolaryngology · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The microbiota may play a role in maintaining and perpetuating inflammation in chronic rhinosinusitis (CRS). This study aimed to induce CRS in rats and evaluate microbiota composition compared to controls. Methods: Sixteen male Wistar rats were used. Eight rats received intranasal instillations of Results: Histopathological changes were more frequent in the CRS group compared to controls, especially mucosal changes (100% vs. 25%; Conclusions: Chronic inflammation induces significant microbiota changes, with an increase of species richness in the CRS group. These findings suggest microbiota shifts may result from inflammatory environments rather than being the primary cause. Level of Evidence: Basic science.
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Registered trials
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