ReviewFrontiers in microbiology2025
Molecular mechanisms and applications of natural transformation in bacteria.
Review in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Genetic Elements Associated with the Acquired Resistome of the Gut Microbiota in a Broiler Rooster Flock in Hungary.Animals : an open access journal from MDPI · 2026Article
- Horizontal gene transfer in Saccharomyces cerevisiae and other Saccharomycotina yeasts: a review.World journal of microbiology & biotechnology · 2026Review
- Genomic and functional dissection of natural transformation-related genes inMicrobiology spectrum · 2026Article
- Functional Analysis of CRISPR-Cas9-Mediated Gene Deletion inMicroorganisms · 2026Article
- Type IV minor pilin ComN predicted the USS-receptor in Pasteurellaceae.Frontiers in microbiology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural transformation is a process in which bacteria uptake exogenous DNA from the environment during a transient physiological state called competence. The DNA can either autonomously replicate or integrate into the bacterial chromosome through homologous recombination. Natural transformation has been studied for nearly a century. Recently, the rapid development of synthetic biology has led to the widespread use of natural transformation as a gene-editing tool for modifying industrial strains. A better understanding of the basic principles of natural transformation can enhance its biotechnological applications. This article provides a detailed overview of the natural transformation process, from initiation to completion. It focuses on the molecular mechanisms involved in natural transformation in both Gram-positive and Gram-negative bacteria. The article also analyzes factors that influence the activation of natural transformation, detailing the regulatory processes and signaling pathways involved. It further explores the potential biological functions of natural transformation. Finally, it discusses various applications of natural transformation in gene editing, offering insights into its potential for modifying industrial strains.
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Registered trials
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