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ArticleFrontiers in nutrition2025

Aging and IGF-I: relationships with vitamin D and body composition. A mediation analysis.

Roberto Vicinanza, Alessandro Frizza, Julie A Pollard, Valentina Mazza, Massimo Ulderico De Martino, Giovanni Imbimbo, Pasquale Pignatelli, Evaristo Ettorre, Maria Del Ben, Alessio Molfino

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Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Roberto VicinanzaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States.
Alessandro FrizzaDepartment of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Julie A PollardLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States.
Valentina MazzaDepartment of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Massimo Ulderico De MartinoDepartment of Human, Philosophical and Educational Sciences, University of Salerno, Salerno, Italy.
Giovanni ImbimboDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Pasquale PignatelliDepartment of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Evaristo EttorreDepartment of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Maria Del BenDepartment of Clinical, Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Alessio MolfinoDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Insulin-like Growth Factor I (IGF-I) and Vitamin D are crucial for growth and metabolism, with their levels declining with age. However, their mutual interactions and contributions to body composition remain unclear. Objectives: To examine the relationships between IGF-I, Vitamin D, and body composition in geriatric outpatients, and to test the mediational role of IGF-I in the association between Vitamin D and Fat-Free Mass (FFM). Methods: One hundred thirty patients were eligible at the Geriatric Outpatient Clinic at the Policlinico Umberto I, Sapienza University of Rome, Italy. Multimorbidity was evaluated with the Cumulative Illness Rating scale for Geriatrics (CIRS-G). Body composition was measured using bioelectrical impedance analysis. Complete blood count, metabolic panel, IGF-I, and 25(OH) Vitamin D were assessed. Results: Ninety-one patients were included in the analysis. Mean age was 74.4 ± 7.2 years; 50.5% female. Mean BMI was 28 kg/m Conclusion: These findings provide further evidence of a positive correlation between IGF-I and lean body mass and suggest that IGF-I may mediate the physiological effect of Vitamin D on FFM, highlighting their potential roles in assessing pre-frailty and personalizing nutrition interventions.

Indexed as

agingbody compositionfat-free massfrailtyIGF-Iinsulin-like growth factor-Imultimorbidityvitamin D

Identifiers

PMID40630171
PMCPMC12234294

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.