ArticleFrontiers in nutrition2025
Associations of self-reported sleep disturbances, sleep onset, and duration with gallstone disease risk.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The role of sleep disturbances in gallstone disease risk remains unclear. We aimed to examine the associations between sleep disturbances and gallstone disease risk. Methods: We analyzed data from 9,059 participants in the NHANES survey (2017-2020). The primary outcome of this study was gallstone disease. Sleep disturbances included trouble sleeping, early or late sleep onset time, and long or short sleep duration. Multivariate logistic regression analysis was employed to evaluate the associations between sleep disturbances and gallstone disease risk. Results: After adjusting for confounding factors, trouble sleeping was associated with an elevated risk of gallstone disease, with the odds ratio (OR) of 1.47 (95% confidence interval [CI]: 1.01-2.15), compared to those without trouble sleeping. In further stratified analysis, among individuals with trouble sleeping, no significant associations were found between different sleep onset intervals, sleep duration and gallstone disease risk. Among participants without trouble sleeping, the sleep onset interval of 23:00 to 00:00 was associated with a significantly increased gallstone disease risk compared to the reference sleep onset interval of 22:00-23:00, with an OR of 1.61 (95% CI: 1.06-2.45). Short sleep duration (<6 h) was associated with a significantly reduced gallstone disease risk compared to the reference sleep duration of 6-8 h, with the OR of 0.43 (95% CI: 0.25-0.75). Conclusion: This study demonstrates that trouble sleeping increases the risk of gallstone formation, independent of sleep onset time and sleep duration. Among those without trouble sleeping, a sleep onset time between 23:00-00:00 is associated with a higher risk, while short sleep duration (< 6 h) appears protective.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.