ArticleFrontiers in nutrition2025
Age differences in the association of prognostic nutritional index quartiles and heart failure in US adults: the NHANES 2011-2018.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- Establishment and validation of an interpretable machine learning-based predictive model for risk of post-PCI in-hospital heart failure in AIHD patients.Frontiers in cardiovascular medicine · 2026Article
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4 authors.
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Abstract
Background: Heart failure (HF) is the leading cause of morbidity and mortality among adults worldwide. Systemic chronic inflammatory, immune dysfunction and malnutrition are considered important characteristics of HF patients. The prognostic nutritional index (PNI) is an emerging indicator for evaluating an individual's immune-inflammatory and nutritional status. However, its relationship with the prevalence of HF is unclear. This study aimed to investigate the relationship between PNI and HF. Methods: This study included 19,965 participants from 2011 to 2018 in the National Health and Nutrition Examination Survey (NHANES) database. Weighted multiple linear regression and logistic regression, adjusted for potential confounders, were used to analyze the association between PNI and HF. Generalized additive modeling (GAM), smoothing curves, and subgroup analyses were also conducted for a deeper understanding. The diagnostic ability of the PNI for HF was assessed by analyzing the receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC). Results: Unadjusted model 1 indicated a negative association between PNI and HF risk (odds ratio (OR) = 0.90, 95% CI: 0.89, 0.92), which persisted in the fully adjusted model 3 (OR = 0.97, 95% CI: 0.95, 0.99). This suggests that each unit increase in PNI reduces the likelihood of developing HF by 3%. When continuous variables were divided into quartiles, quartile 4 had a 52% lower PNI than quartile 1 (OR = 0.48, 95% CI: 0.39, 0.56). Subgroup analyses showed a significant interaction between age and the correlation between PNI and HF (interaction Conclusions: The higher PNI is significantly associated with a lower prevalence of HF, particularly in the nonelderly population (20-59 years). This suggests that PNI may serve as a valuable screening tool for HF risk, emphasizing the importance of nutritional and immune status in HF development.
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