SynthesisFrontiers in nutrition2025
Association between gastroesophageal reflux and bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- [Association between early transpyloric feeding and the risk of bronchopulmonary dysplasia in very preterm/extremely preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Chronic respiratory morbidity and wheeze after preterm birth: a narrative review.Frontiers in pediatrics · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Gastroesophageal reflux (GER) has emerged as a potential contributor to lung injury. This meta-analysis aimed to evaluate the association between GER and bronchopulmonary dysplasia (BPD) in preterm infants. Methods: A systematic literature search was conducted in PubMed, Embase, Web of Science, and Cochrane Library databases up to Oct 19, 2024. Studies assessing the association between BPD and GER in preterm infants were included. Random-effects models was used to calculate pooled risk ratios (RR) with 95% confidence intervals (CIs). Sensitivity analyses and subgroup analyses were performed to assess the robustness of the findings. Results: Seven studies were included in the meta-analysis. The overall analysis revealed a non-significant association between GER and BPD (RR = 1.35, 95% CI = 0.91-2.01), but significant heterogeneity was observed across the studies ( Conclusion: Preterm infants with clinically diagnosed GER may face an elevated risk of developing BPD. GER diagnosed by pH monitoring was not associated with BPD. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/.
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