Trial reportActa ophthalmologica2026
A randomised controlled trial on cross-linking protocols for the treatment of progressive keratoconus using isoosmolar and hypoosmolar riboflavin with the addition of sterile water in thin corneae.
Trial report in Acta ophthalmologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of epithelium-off versus iontophoresis-assisted transepithelial corneal collagen cross-linking in keratoconus: a systematic review and meta-analysis.International ophthalmology · 2026Pooled it
- A randomised controlled trial on cross-linking protocols for the treatment of progressive keratoconus using isoosmolar and hypoosmolar riboflavin with the addition of sterile water in thin corneae.Acta ophthalmologica · 2026Trial
- Degradable Suture-Free Scaffold to Induce Therapeutic Ridge Formation and to Control Eye Elongation: A Potential Treatment for Pathological Myopia.Translational vision science & technology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeTo present the outcomes of a randomised clinical trial for the treatment of progressive keratoconus using different kinds of riboflavin and the addition of sterile water in thin corneae.
methodsA randomised study using epithelium-off corneal cross-linking (CXL) with continuous UVA irradiance 9 mW/cm PRIMARY OUTCOME: Change in Kmax.
resultsThere were no statistically significant differences in any of the parameters between the isoosmolar and hypoosmolar groups. In the isoosmolar group, 74% of the patients required the addition of sterile water, while only 15% required it in the hypoosmolar group. The measurements of densitometry in the 0-2 mm zone improved less in the group that received sterile water; otherwise, there were no statistically significant differences in any of the parameters between the groups that did and did not receive the addition of sterile water.
conclusionsThe results of this study demonstrate the efficacy and safety in using hypoosmolar riboflavin when performing CXL for progressive keratoconus. The results also demonstrate the efficacy and safety of using sterile water in corneae thinner than 400 μm.
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Registered trials
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