Evidence map›Paper›PMID 40629913›Full record

SynthesisDiabetic medicine : a journal of the British Diabetic Association2025

Effectiveness of dietary interventions in individuals with diabetes for preventing and healing chronic wounds; a systematic review with meta-analysis.

Hailey R Donnelly, Clare E Collins, Erin D Clarke, Prudence I Morrissey, Natalie Gilbertson-Viljevac, Lucy Leigh, Peta E Tehan

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetic medicine : a journal of the British Diabetic Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hailey R DonnellySchool of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.ORCID https://orcid.org/0000-0002-4027-8950
Clare E CollinsSchool of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.
Erin D ClarkeSchool of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.
Prudence I MorrisseySchool of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.
Natalie Gilbertson-ViljevacSchool of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.
Lucy LeighSchool of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.
Peta E TehanSchool of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.

Funding

National Health and Medical Research CouncilUniversity of Newcastle Australia
6 · The paper itself

Abstract

backgroundOptimising the nutritional status of individuals with diabetes is essential to optimise glycaemic control, as well as to prevent and promote wound healing. A variety of nutrition interventions are available. This systematic review and meta-analysis aimed to describe and synthesise the effectiveness of nutrition interventions for the prevention and management of chronic wounds in people with diabetes.

methodsFive databases and four clinical trial registries were searched for nutrition intervention studies. Included studies involved a nutrition intervention, such as personalised medical nutrition therapy, education and/or nutrient supplementation for those with diabetes and a chronic wound. Meta-analysis was completed utilising mean wound size at follow-up and non-adjusted data where available. Quality was appraised using RoB 2 and ROBINS, and certainty of evidence was assessed using GRADE.

resultsTwenty-three studies were included; all included studies were in diabetes-related foot ulcer populations. Meta-analyses demonstrated nutrient supplements, including single and multi-nutrient supplements, significantly reduced wound depth (MWD -0.200 [95% CI -0.364, -0.035], p = 0.0172), width (WMD -0.466 [95% CI -0.724, -0.208], p = 0.0004) and length (-0.443 [95% CI -0.841, -0.045], p = 0.0292), the quality of included studies was low and the certainty of evidence was very low. While substantial heterogeneity was detected (I

conclusionThere is low-quality evidence that nutrient supplementation improves wound healing. Nutrition education may have a role in enhancing wound size reduction. Further studies are needed using robust methodologies to comprehensively determine the effectiveness of nutrition interventions for wound healing.

Indexed as

Diabetes MellitusDiabetic FootDietary SupplementsNutrition TherapyWound HealingChronic DiseaseHumansNutritional Statusdiabetesdiabetes‐related foot ulcerdietdietarynutrition interventionsystematic reviewwounds

Identifiers

PMID40629913
PMCPMC12352720

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.