Evidence map›Paper›PMID 40629906›Full record

ArticleActa biochimica et biophysica Sinica2025

Substrate topography-induced osteogenesis of bone marrow stem cells by reducing the chromatin accessibility of YBX1.

Yan Lv, Weishu Dai, Huijing Zhang, Sirui Liu, Mengdie Liu, Xueyan Zhang, Luling Li, Ying Hu, Yi Liu, Lin Song

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In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan LvBeijing Institute of Dental Research, Beijing Stomatological Hospital, Capital Medical University, Beijing 100070, China.
Weishu DaiBeijing Institute of Dental Research, Beijing Stomatological Hospital, Capital Medical University, Beijing 100070, China.
Huijing ZhangDepartment of Periodontology, Beijing Stomatological Hospital, Capital Medical University, Beijing 100070, China.
Sirui LiuBeijing Institute of Dental Research, Beijing Stomatological Hospital, Capital Medical University, Beijing 100070, China.
Mengdie LiuThe Third Medical Center of PLA General Hospital, Beijing 100039, China.
Xueyan ZhangBeijing Institute of Dental Research, Beijing Stomatological Hospital, Capital Medical University, Beijing 100070, China.
Luling LiBeijing Institute of Dental Research, Beijing Stomatological Hospital, Capital Medical University, Beijing 100070, China.
Ying HuBeijing Institute of Dental Research, Beijing Stomatological Hospital, Capital Medical University, Beijing 100070, China.
Yi LiuDepartment of Periodontology, Beijing Stomatological Hospital, Capital Medical University, Beijing 100070, China.
Lin SongDepartment of Periodontology, Beijing Stomatological Hospital, Capital Medical University, Beijing 100070, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cell fate is profoundly influenced by a complex interplay of biochemical and biophysical cues, with the latter increasingly recognized for its roles in cellular processes, yet the mechanisms are unclear. Since chromatin accessibility is a critical determinant in the processes of osteogenesis and bone repair, investigating the contributions of open chromatin regions (OCRs) to the intracellular signaling pathways triggered by topographical cues, which lead to osteogenic differentiation is highly valuable. This study explores the impact of the nanotopography of biomaterials on the osteogenic differentiation of human bone marrow stem cells (hBMSCs). By utilizing electrospun poly-L-lactide (PLLA) membranes with random fiber arrangements, we mimic the natural extracellular matrix (ECM) topography to study its effects on hBMSCs, contrasting them with flat PLLA controls. Through high-throughput Assay for Transposase-Accessible Chromatin with sequencing (ATAC-seq) and RNA sequencing (RNA-seq), we reveal that the nanotopography of electrospun surfaces promotes osteogenic differentiation by modulating the chromatin accessibility of the

Indexed as

Bone Marrow CellsChromatinMesenchymal Stem CellsOsteogenesisY-Box-Binding Protein 1Cell DifferentiationCells, CulturedExtracellular MatrixHumansPolyestersChromatinPolyesterspoly(lactide)Y-Box-Binding Protein 1YBX1 protein, humanbone marrow mesenchymal stem cellchromatin accessibilityosteogenesissubstrate topographyYBX1

Identifiers

PMID40629906
PMCPMC12666669

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.