ArticleRenal failure2025
Single-cell chromatin accessibility landscape of T cell-mediated rejection and BK polyomavirus-associated nephropathy after kidney transplantation.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Ferrostatin-1-loaded black phosphorus quantum dots (BPQD@Fer-1) nanodelivery system attenuates T cell-mediated rejection after kidney transplantation.Materials today. Bio · 2026Article
- Updates in the Diagnosis and Treatment of BK Viraemia in Kidney Transplant Recipients: Current and Future Insights.Journal of clinical medicine · 2025Review
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Authors and funding
5 authors.
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Abstract
Both T cell-mediated rejection (TCMR) and BK polyomavirus-associated nephropathy (BKPyVAN) pose significant obstacles to successful kidney transplantation, emphasizing the importance of their accurate diagnosis for prompt medical intervention. Unfortunately, our current understanding of the molecular characteristics of these conditions is still limited, hampering the development of diagnosis strategies. In this study, we employed the single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) to unravel the chromatin landscape of kidney samples affected by either TCMR or BKPyVAN at the single-cell level. Our findings uncover distinct cell population dynamics and identify enriched pathways in the chromatin changes of TCMR and BKPyVAN samples, providing resources for further characterization of their molecular features. Furthermore, we analyzed the upstream transcriptional and epigenetic regulators modulating the chromatin landscape of each cell population in TCMR and BKPyVAN samples, shedding light on the identification of molecular mechanisms regulating TCMR and BKPyVAN.
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