ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Subcortical gray matter volumes and 5-year dementia risk in individuals with subjective cognitive decline or mild cognitive impairment: A multi-cohort analysis.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Review
- Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neuropathology patterns.bioRxiv : the preprint server for biology · 2025Article
- Subcortical gray matter volumes and 5-year dementia risk in individuals with subjective cognitive decline or mild cognitive impairment: A multi-cohort analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
introductionThe prognostic value of subcortical gray matter structures for dementia beyond the hippocampus remains unclear.
methodsWe included participants with subjective cognitive decline or mild cognitive impairment from two memory clinic-based cohorts (Amsterdam Dementia Cohort and National Alzheimer's Coordinating Center) and one population-based cohort (Rotterdam Study). We assessed volumes of subcortical structures on magnetic resonance imaging and determined 5-year dementia risk using Cox models.
resultsOf 7076 participants (mean age: 66-69 years, 58.8%-61.0% women; N DISCUSSION: Hippocampal and amygdalar volume are consistently associated with dementia risk in individuals with subjective cognitive decline or mild cognitive impairment, which may hold potential for personalized prognosis. HIGHLIGHTS: Seven thousand seventy-six participants from three large longitudinal cohorts were followed for a maximum of 5 years. Hippocampal volume is associated with 5-year risk of dementia in subjective cognitive decline (SCD) or mild cognitive impairment (MCI). Amygdalar volume is associated with a 5-year risk of dementia in SCD or MCI. Stratifying by SCD and MCI revealed no consistent major differences.
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