Evidence map›Paper›PMID 40629711›Full record

ReviewThe clinical respiratory journal2025

Telomere Shortening in Interstitial Lung Disease: Challenges and Promises.

Haonan Jin, Jiamin Song, Ronglin Gao, Bingxian Sha, Shengyuan Wang, Peiming Luo, Li Yu, Xianghuai Xu, Xuan Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The clinical respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haonan JinDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiamin SongDepartment of Rheumatology and Immunology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0001-9815-8508
Ronglin GaoDepartment of Rheumatology and Immunology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-4507-480X
Bingxian ShaDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Shengyuan WangDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0003-1245-2998
Peiming LuoDepartment of Rheumatology and Immunology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Li YuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-1054-017X
Xianghuai XuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-8713-5332
Xuan WangDepartment of Rheumatology and Immunology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-6588-2951

Funding

National Natural Science Foundation of China 81801601National Natural Science Foundation of China 82070102National Natural Science Foundation of China 82270114Program of Shanghai Academic Research Leader 22XD1422700The Project of Science and Technology Commission of Shanghai Municipality 20Y11911600The Project of Science and Technology Commission of Shanghai Municipality 21Y11901400The Project of Science and Technology Commission of Shanghai Municipality 22Y11901300
6 · The paper itself

Abstract

Interstitial lung disease (ILD) is a group of diseases involving diffuse pulmonary parenchymal lesions and alveolar inflammation and interstitial fibrosis. Telomeres are repetitive DNA sequences at the end of chromosomes to maintain structural integrity and telomerase can prevent telomere shortening. Telomerase abnormalities such as related gene mutations lead to decrease in telomerase activity and telomere shortening. It has been proven that telomere shortening and telomerase abnormalities are related to the occurrence and development of ILD. Telomere shortening occurs in different types of ILD patients and is associated with prognosis. Gene therapy targeting telomerase exhibits therapeutic potential. The paper elaborates on the progress of telomere shortening in the diagnosis, differential diagnosis, treatment, and prognosis of ILD in recent years, in order to demonstrate its potential and promises and to be helpful for clinical diagnosis and treatment.

Indexed as

Lung Diseases, InterstitialTelomeraseTelomereTelomere ShorteningDiagnosis, DifferentialGenetic TherapyHumansMutationPrognosisTelomeraseconnective tissue diseaseinterstitial lung diseasepulmonary fibrosistelomerasetelomere

Identifiers

PMID40629711
PMCPMC12238310

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.