ArticleMedicine2025
Mesenchymal stem cells and knee osteoarthritis: A bibliometric analysis.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesMesenchymal stem cells (MSCs) are characterized by self-renewal and multidirectional differentiation, indicating that they have great application prospects in the treatment of knee osteoarthritis (KOA). The purpose of this study was to explore the research status, hot spots and future research trends of the use of MSCs in KOA treatment and to provide a basis for research directions and applications in this field.
methodsWe searched the Web of Science Core Collection database from 2012 to 2022 to identify literature related to the use of MSCs for the treatment of KOA. All the included studies were subjected to bibliometric analysis via Hiplot Pro and CiteSpace software to produce statistics and visual analyses of data, including the nation, institution, author, keyword and reference.
resultsA total of 1537 studies were analyzed. These studies had been cited 41,916 times. The 3 countries with the greatest number of published papers were the USA (415), China (374), and Italy (130). Two U.S.-based institutions, i.e., Hospital for Special Surgery and Rush University, had the greatest number of published papers. The representative journals in this field were Stem Cells, Annals of Rheumatic Diseases, Osteoarthritis and Cartage and the American Journal of Sports Medicine. Keyword co-occurrence and co-citation reference analyses revealed that the key research theme in this field in the past decade has been the efficacy and mechanism of MSCs for treating KOA (articular cartilage). These findings preliminarily confirmed the clinical value of MSCs for treating KOA.
conclusionsThe use of MSCs to treat KOA has great potential for clinical application and has been widely studied by researchers. The clinical efficacy and mechanism of action of MSCs are still the core content. In KOA treatment, adipose-derived MSCs, MSC-derived exosomes and the risk of MSC application are future research areas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.